β               2‐GPI‐dependent and independent binding of anticardiolipin antibodies in patients with recurrent spontaneous abortions

Nobuaki Ozawa; Tsunehisa Makino; Hidehiko Matsubayashi; Tomotoshi Hosokawa; Ken‐Ichi ‐I Someya; Shiro Nozawa; Eiji Matsuura

doi:10.1002/jcla.1860080502

β ₂‐GPI‐dependent and independent binding of anticardiolipin antibodies in patients with recurrent spontaneous abortions

Nobuaki Ozawa, Tsunehisa Makino, Hidehiko Matsubayashi, Tomotoshi Hosokawa, Ken‐Ichi ‐I Someya, Shiro Nozawa, Eiji Matsuura

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

We measured anticardiolipin antibodies (aCL) in plasma samples from 214 women with a history of recurrent spontaneous abortions by an enzyme‐linked immunosorbent assay (ELISA) utilizing solid phase cardiolipin (CL) and β₂‐glycoprotein I (β₂‐GPI). Sixteen patients (7.5%) were positive for β₂‐GPI‐dependent aCL. Though β₂‐GPI appeared to enhance the binding of aCL, β₂‐GPI‐independent aCL were also observed in these patients (4.7%). The patients were classified into three groups on the basis of their medical history, and analysis of data of individual groups revealed that the incidence of β₂‐GPI‐dependent aCL was significantly higher in patients who had experienced at least one fetal loss in the second or third trimester. © 1994 Wiley‐Liss, Inc.

Original language	English
Pages (from-to)	255-259
Number of pages	5
Journal	Journal of Clinical Laboratory Analysis
Volume	8
Issue number	5
DOIs	https://doi.org/10.1002/jcla.1860080502
Publication status	Published - 1994
Externally published	Yes

Keywords

SLE (systemic lupus erythematosus)
antiphospholipid syndrome
cofactor
habitual abortion
thrombosis

ASJC Scopus subject areas

Immunology and Allergy
Hematology
Public Health, Environmental and Occupational Health
Clinical Biochemistry
Medical Laboratory Technology
Biochemistry, medical
Microbiology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/jcla.1860080502

Cite this

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title = "β 2‐GPI‐dependent and independent binding of anticardiolipin antibodies in patients with recurrent spontaneous abortions",

abstract = "We measured anticardiolipin antibodies (aCL) in plasma samples from 214 women with a history of recurrent spontaneous abortions by an enzyme‐linked immunosorbent assay (ELISA) utilizing solid phase cardiolipin (CL) and β2‐glycoprotein I (β2‐GPI). Sixteen patients (7.5%) were positive for β2‐GPI‐dependent aCL. Though β2‐GPI appeared to enhance the binding of aCL, β2‐GPI‐independent aCL were also observed in these patients (4.7%). The patients were classified into three groups on the basis of their medical history, and analysis of data of individual groups revealed that the incidence of β2‐GPI‐dependent aCL was significantly higher in patients who had experienced at least one fetal loss in the second or third trimester. {\textcopyright} 1994 Wiley‐Liss, Inc.",

keywords = "SLE (systemic lupus erythematosus), antiphospholipid syndrome, cofactor, habitual abortion, thrombosis",

author = "Nobuaki Ozawa and Tsunehisa Makino and Hidehiko Matsubayashi and Tomotoshi Hosokawa and Someya, {Ken‐Ichi ‐I} and Shiro Nozawa and Eiji Matsuura",

year = "1994",

doi = "10.1002/jcla.1860080502",

language = "English",

volume = "8",

pages = "255--259",

journal = "Journal of Clinical Laboratory Analysis",

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T1 - β 2‐GPI‐dependent and independent binding of anticardiolipin antibodies in patients with recurrent spontaneous abortions

AU - Ozawa, Nobuaki

AU - Makino, Tsunehisa

AU - Matsubayashi, Hidehiko

AU - Hosokawa, Tomotoshi

AU - Someya, Ken‐Ichi ‐I

AU - Nozawa, Shiro

AU - Matsuura, Eiji

PY - 1994

Y1 - 1994

N2 - We measured anticardiolipin antibodies (aCL) in plasma samples from 214 women with a history of recurrent spontaneous abortions by an enzyme‐linked immunosorbent assay (ELISA) utilizing solid phase cardiolipin (CL) and β2‐glycoprotein I (β2‐GPI). Sixteen patients (7.5%) were positive for β2‐GPI‐dependent aCL. Though β2‐GPI appeared to enhance the binding of aCL, β2‐GPI‐independent aCL were also observed in these patients (4.7%). The patients were classified into three groups on the basis of their medical history, and analysis of data of individual groups revealed that the incidence of β2‐GPI‐dependent aCL was significantly higher in patients who had experienced at least one fetal loss in the second or third trimester. © 1994 Wiley‐Liss, Inc.

AB - We measured anticardiolipin antibodies (aCL) in plasma samples from 214 women with a history of recurrent spontaneous abortions by an enzyme‐linked immunosorbent assay (ELISA) utilizing solid phase cardiolipin (CL) and β2‐glycoprotein I (β2‐GPI). Sixteen patients (7.5%) were positive for β2‐GPI‐dependent aCL. Though β2‐GPI appeared to enhance the binding of aCL, β2‐GPI‐independent aCL were also observed in these patients (4.7%). The patients were classified into three groups on the basis of their medical history, and analysis of data of individual groups revealed that the incidence of β2‐GPI‐dependent aCL was significantly higher in patients who had experienced at least one fetal loss in the second or third trimester. © 1994 Wiley‐Liss, Inc.

KW - SLE (systemic lupus erythematosus)

KW - antiphospholipid syndrome

KW - cofactor

KW - habitual abortion

KW - thrombosis

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