(2-Pyridyldimethylsilyl)methyl lithium as a novel hydroxymethylating reagent

Kenichiro Itami, Koichi Mitsudo, Jun ichi Yoshida

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


(2-Pyridyldimethylsilyl)methyl lithium was found to react with organic bromides, aldehydes, ketones, and hydrosilanes in good to excellent yields. The resultant adducts were further oxidized with H2O2/KF to give the corresponding alcohols in excellent yields. Thus, this two-step transformation provides an efficient method for hydroxymethylation.

Original languageEnglish
Pages (from-to)5537-5540
Number of pages4
JournalTetrahedron Letters
Issue number30
Publication statusPublished - Jul 1999
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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