2,3-Dimethoxyindolines: a latent electrophile for SNAr reactions triggered by indium catalysts

Seiya Hirao, Toshiki Yamashiro, Kyouka Kohira, Naoki Mishima, Takumi Abe

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


2,3-Dimethoxyindolines (DiMeOINs) have emerged as a latent electrophile in indium-catalyzed SNAr reactions. They are easily obtained from commercially available indoles and allowed access to 3-substituted indoles. The reaction proceedsviaSNAr reactions ofin situgenerated 3-methoxyindoles. Formation of C2-substituted indoles was also possible utilizing the C2-nucleophilicity of DIMeOIN. Our protocol is user friendly as DiMeOIN is a bench-stable easy-to-handle crystalline reagent.

Original languageEnglish
Pages (from-to)5139-5142
Number of pages4
JournalChemical Communications
Issue number38
Publication statusPublished - May 11 2020
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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