5-HT1A receptor full agonist, 8-OH-DPAT, exerts antidepressant-like effects in the forced swim test in ACTH-treated rats

Yoshihisa Kitamura; Hiroaki Araki; Kazuhiko Shibata; Yutaka Gomita; Yoshiro Tanizaki

doi:10.1016/j.ejphar.2003.09.008

5-HT_1A receptor full agonist, 8-OH-DPAT, exerts antidepressant-like effects in the forced swim test in ACTH-treated rats

Yoshihisa Kitamura, Hiroaki Araki, Kazuhiko Shibata, Yutaka Gomita, Yoshiro Tanizaki

University Hospital

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

We examined the effect of adrenocorticotropic hormone (ACTH) on the immobilization of rats in the forced swim test after administration of the 5-HT_1A receptor agonist, 8-hydroxy-2-di-n-propylamino tetralin (8-OH-DPAT). Imipramine (3-30 mg/kg, i.p.) or 8-OH-DPAT (0.1-1 mg/kg, s.c.) significantly decreased the duration of immobility in normal rats. The immobility-decreasing effect of imipramine was blocked when ACTH was administered for 14 days. On the other hand, the immobility-decreasing effect induced by 8-OH-DPAT was not blocked by chronic administration of ACTH for 14 days. These findings indicate that 8-OH-DPAT can be useful in an animal model of depressive conditions resistant to antidepressant treatment.

Original language	English
Pages (from-to)	75-77
Number of pages	3
Journal	European Journal of Pharmacology
Volume	481
Issue number	1
DOIs	https://doi.org/10.1016/j.ejphar.2003.09.008
Publication status	Published - Nov 14 2003

Keywords

5-HT receptor
8-OH-DPAT (8-hydroxy-2-di-n-propylamino tetralin)
Depression treatment-resistant
Forced swim test
Imipramine

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/j.ejphar.2003.09.008

Cite this

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title = "5-HT1A receptor full agonist, 8-OH-DPAT, exerts antidepressant-like effects in the forced swim test in ACTH-treated rats",

abstract = "We examined the effect of adrenocorticotropic hormone (ACTH) on the immobilization of rats in the forced swim test after administration of the 5-HT1A receptor agonist, 8-hydroxy-2-di-n-propylamino tetralin (8-OH-DPAT). Imipramine (3-30 mg/kg, i.p.) or 8-OH-DPAT (0.1-1 mg/kg, s.c.) significantly decreased the duration of immobility in normal rats. The immobility-decreasing effect of imipramine was blocked when ACTH was administered for 14 days. On the other hand, the immobility-decreasing effect induced by 8-OH-DPAT was not blocked by chronic administration of ACTH for 14 days. These findings indicate that 8-OH-DPAT can be useful in an animal model of depressive conditions resistant to antidepressant treatment.",

keywords = "5-HT receptor, 8-OH-DPAT (8-hydroxy-2-di-n-propylamino tetralin), Depression treatment-resistant, Forced swim test, Imipramine",

author = "Yoshihisa Kitamura and Hiroaki Araki and Kazuhiko Shibata and Yutaka Gomita and Yoshiro Tanizaki",

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AU - Kitamura, Yoshihisa

AU - Araki, Hiroaki

AU - Shibata, Kazuhiko

AU - Gomita, Yutaka

AU - Tanizaki, Yoshiro

PY - 2003/11/14

Y1 - 2003/11/14

N2 - We examined the effect of adrenocorticotropic hormone (ACTH) on the immobilization of rats in the forced swim test after administration of the 5-HT1A receptor agonist, 8-hydroxy-2-di-n-propylamino tetralin (8-OH-DPAT). Imipramine (3-30 mg/kg, i.p.) or 8-OH-DPAT (0.1-1 mg/kg, s.c.) significantly decreased the duration of immobility in normal rats. The immobility-decreasing effect of imipramine was blocked when ACTH was administered for 14 days. On the other hand, the immobility-decreasing effect induced by 8-OH-DPAT was not blocked by chronic administration of ACTH for 14 days. These findings indicate that 8-OH-DPAT can be useful in an animal model of depressive conditions resistant to antidepressant treatment.

AB - We examined the effect of adrenocorticotropic hormone (ACTH) on the immobilization of rats in the forced swim test after administration of the 5-HT1A receptor agonist, 8-hydroxy-2-di-n-propylamino tetralin (8-OH-DPAT). Imipramine (3-30 mg/kg, i.p.) or 8-OH-DPAT (0.1-1 mg/kg, s.c.) significantly decreased the duration of immobility in normal rats. The immobility-decreasing effect of imipramine was blocked when ACTH was administered for 14 days. On the other hand, the immobility-decreasing effect induced by 8-OH-DPAT was not blocked by chronic administration of ACTH for 14 days. These findings indicate that 8-OH-DPAT can be useful in an animal model of depressive conditions resistant to antidepressant treatment.

KW - 5-HT receptor

KW - 8-OH-DPAT (8-hydroxy-2-di-n-propylamino tetralin)

KW - Depression treatment-resistant

KW - Forced swim test

KW - Imipramine

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