TY - GEN
T1 - A bio-thermochemical sensor of microbolometer immobilized liposome for detection of causative protein of Alzheimer's disease, amyloid beta
AU - Noda, Minoru
AU - Asai, Takeshi
AU - Yamashita, Kaoru
AU - Shimanouchi, Toshinori
AU - Umakoshi, Hiroshi
AU - Okuyama, Masanori
AU - Kuboi, Ryouichi
N1 - Funding Information:
This research was supported in part by Grants-in-Aid for Scientific Research (No. 19360162, 21246121, 20760539) from the Japan Society for the Promotion of Science. It was partly supported by the Core University Program between JSPS and VAST.
PY - 2009
Y1 - 2009
N2 - Forming process of liposome droplet and its stable immobilization on a Si-based microbolometer are investigated and applied for detection of causative protein of Alzheimer's disease, amyloid β (Aβ) protein, where the disease is closely related to the amyloid fibril formation. This work is a preliminary but innovative approach applying a bio-thermochemical microsensor to monitor the formation. It is observed that the bolometer surface keeps a long time intact behavior of the liposome up to 24 hours. It seems from time course results with Aβ that the variation in the temperature profile corresponds to that observed in fluorescence analysis result of the formation.
AB - Forming process of liposome droplet and its stable immobilization on a Si-based microbolometer are investigated and applied for detection of causative protein of Alzheimer's disease, amyloid β (Aβ) protein, where the disease is closely related to the amyloid fibril formation. This work is a preliminary but innovative approach applying a bio-thermochemical microsensor to monitor the formation. It is observed that the bolometer surface keeps a long time intact behavior of the liposome up to 24 hours. It seems from time course results with Aβ that the variation in the temperature profile corresponds to that observed in fluorescence analysis result of the formation.
UR - http://www.scopus.com/inward/record.url?scp=77951101742&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951101742&partnerID=8YFLogxK
U2 - 10.1109/ICSENS.2009.5398264
DO - 10.1109/ICSENS.2009.5398264
M3 - Conference contribution
AN - SCOPUS:77951101742
SN - 9781424445486
T3 - Proceedings of IEEE Sensors
SP - 836
EP - 839
BT - IEEE Sensors 2009 Conference - SENSORS 2009
T2 - IEEE Sensors 2009 Conference - SENSORS 2009
Y2 - 25 October 2009 through 28 October 2009
ER -