Abstract
Appropriate model cell lines recapitulating cancer stem cell (CSC) properties would accelerate not only investigation of cancer stem cells but also development of new clinical cancer therapy by establishing a screening system for anti-cancer stem cell agents. In this chapter, the authors introduce their recent work and others to generate cells with cancer stem cell properties in vitro. They also discuss the concept of cancer stem cells with results obtained from originally established cancer stem-like cells. Finally, they describe future applications of the model to basic and clinical studies. In the field of regeneration therapy, the pluripotent stem cells such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are promising sources of differentiated cells for transplantation. Interestingly, these cancer stem-like cells were not required to be introduced with the genes for cell surface markers that are commonly used to characterize and isolate cancer stem cells.
| Original language | English |
|---|---|
| Title of host publication | Cancer Stem Cells |
| Publisher | Wiley Blackwell |
| Pages | 79-87 |
| Number of pages | 9 |
| Volume | 9781118356166 |
| ISBN (Electronic) | 9781118356203 |
| ISBN (Print) | 9781118356166 |
| DOIs | |
| Publication status | Published - Apr 14 2014 |
Keywords
- Cancer stem cell (CSC) model
- Cancer stem-like cells
- Embryonic stem cells (ESCs)
- Induced pluripotent stem cells
- Induced pluripotent stem cells (iPSCs)
- Regeneration therapy
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
