A case-matched comparative study of laparoscopic and open total proctocolectomy for ulcerative colitis

Ryo Inada, Takeshi Nagasaka, Yoshitaka Kondo, Ayako Watanabe, Toshiaki Toshima, Nobuhito Kubota, Satoru Kikuch, Michihiro Ishida, Shinji Kuroda, Yoshiko Mori, Hiroyuki Kishimoto, Toshiyoshi Fujiwara

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


The aim of this single-institution, retrospective, observational case-control study was to evaluate the safety and feasibility of laparoscopic proctocolectomy (PC) for ulcerative colitis (UC), by comparing it with a case-control series of open PC. Twenty UC patients who underwent laparoscopic PC were retrospectively compared with the open PC group of 12 patients matched for age, sex, and urgency of the operation. In the laparoscopic PC group, the operative time was significantly longer, but the amount of blood loss was significantly smaller. The open PC patients underwent an intraoperative blood transfusion significantly more often, and the serum C-reactive protein level on the first postoperative day was significantly higher in the open PC group. In the laparoscopic PC group, the rate of severe postoperative morbidities, grades 3 and 4 on the Clavien-Dindo classification, was significantly lower, and the median length of hospital stay was significantly shorter. Laparoscopic PC for patients with UC showed superior perioperative outcomes to open PC, except for longer operative time.

Original languageEnglish
Pages (from-to)267-273
Number of pages7
JournalActa medica Okayama
Issue number5
Publication statusPublished - 2015


  • Casematched study
  • Laparoscopic surgery
  • Open proctocolectomy
  • Total proctocolectomy
  • Ulcerative colitis

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology


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