A case of carcinoma showing thymus-like differentiation with a rapidly lethal course

Tomohiro Nogami, Naruto Taira, Shinichi Toyooka, Takehiro Tanaka, Taeko Mizoo, Takayuki Iwamoto, Tadahiko Shien, Junichi Sou, Shinichiro Miyoshi, Hiroyoshi Doihara

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


A 55-year-old woman underwent a total thyroidectomy for carcinoma showing thymus-like differentiation (CASTLE). The patient was referred to our hospital after the tumor was found to have directly invaded the cervical esophagus and the entire circumference of the trachea. A total thyroidectomy was performed, followed by end-to-end anastomosis of the trachea, suprahyoid release and dissection of bilateral pulmonary ligaments. No major complications, including anastomotic dehiscence or stenosis, were observed. The patient experienced some swallowing disturbances and hoarseness during the perioperative period but fully recovered. Radiotherapy to the neck was performed as an adjuvant therapy. Eleven months after surgery, lower back pain and right leg numbness developed and led to gait inability. Multiple lung and bone recurrences were observed, but no local recurrence. Palliative radiotherapy to the bone metastasis was performed. The patient died of pleural metastasis 14 months after the initial diagnosis of CASTLE.

Original languageEnglish
Pages (from-to)840-844
Number of pages5
JournalCase Reports in Oncology
Issue number3
Publication statusPublished - Apr 12 2014


  • Carcinoma showing thymus-like differentiation
  • Infiltrating trachea
  • Reconstruction

ASJC Scopus subject areas

  • Oncology


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