A case of chroic hyperplatic oral candidiasis treated with effective medicines

Nobuyoshi Mizukawa, Yutaka Nishijima, Katsumi Nishijima, Norihiro Miyoshi, Takayuki Mori

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Chronic hyperplastic oral candidiasis is a disease which features the development of white lesions resembling leukoplakia. Although there have been a number of reports on this disease from foreign countries, it has rarely been reported in Japan. This disease is basically treated with antifungal agents. However, it often requires longterm therapy, and epithelial dysplasia may remain in some cases, even after the fungus has been eliminated. Moreover, since malignant transformation has been reported, surgical excision should be performed when the disease has run an excessively long course. The experience with a patient, who was histopathologically diagnosed as having chronic hyperplastic oral candidiasis is reported. A summary of this case is presented along with a reviw of the literature. A 67-year-old man visited our clinic with the chief complaint of bilateral buccal mucosal pain while eating. After making a clinical diagnosis of lichen planus, biopsy was performed, resulting in a histopathological diagnosis of chronic hyperplastic oral candidiasis. With antifungal therapy, the lesions disappeared within three months after diagnosis at our clinic. The patient has not relapsed up to the present (January 31, 1995).

Original languageEnglish
Pages (from-to)138-140
Number of pages3
Issue number2
Publication statusPublished - 1995


  • antifungal therapy
  • candidiasis
  • leukoplakia

ASJC Scopus subject areas

  • Dentistry(all)
  • Pharmacology
  • Pharmacology (medical)


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