A case of diffuse panbronchiolitis, associated with severe pulmonary hypertension, managed with bilateral lung transplantation from a brain-dead donor

Yasutaka Onishi; Tetsuji Kawamura; Akie Morimoto; Yasuharu Nakahara; Yoshiro Mochizuki; Kentaroh Miyoshi; Takahiro Oto

doi:10.1016/j.resinv.2015.03.001

A case of diffuse panbronchiolitis, associated with severe pulmonary hypertension, managed with bilateral lung transplantation from a brain-dead donor

Yasutaka Onishi, Tetsuji Kawamura, Akie Morimoto, Yasuharu Nakahara, Yoshiro Mochizuki, Kentaroh Miyoshi, Takahiro Oto

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Diffuse panbronchiolitis (DPB) is a chronic respiratory disease that mainly involves the respiratory bronchioles, and has historically been associated with a very poor prognosis. The development of long-term low dose macrolide therapy in the 1980s has dramatically improved the prognosis of DPB. Nevertheless, some cases are resistant to macrolide therapy, and ultimately develop severe respiratory failure and pulmonary hypertension; in such cases lung transplantation is a viable treatment option. Here we report the case of a 40-year-old patient with a 20-year history of DPB, who underwent bilateral lung transplantation due to severe respiratory failure with pulmonary hypertension.

Original language	English
Pages (from-to)	242-246
Number of pages	5
Journal	Respiratory Investigation
Volume	53
Issue number	5
DOIs	https://doi.org/10.1016/j.resinv.2015.03.001
Publication status	Published - Sept 1 2015

Keywords

Brain-dead donor
Chronic sinusitis
Diffuse panbronchiolitis
Lung transplantation
Pulmonary hypertension

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.resinv.2015.03.001

Cite this

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title = "A case of diffuse panbronchiolitis, associated with severe pulmonary hypertension, managed with bilateral lung transplantation from a brain-dead donor",

abstract = "Diffuse panbronchiolitis (DPB) is a chronic respiratory disease that mainly involves the respiratory bronchioles, and has historically been associated with a very poor prognosis. The development of long-term low dose macrolide therapy in the 1980s has dramatically improved the prognosis of DPB. Nevertheless, some cases are resistant to macrolide therapy, and ultimately develop severe respiratory failure and pulmonary hypertension; in such cases lung transplantation is a viable treatment option. Here we report the case of a 40-year-old patient with a 20-year history of DPB, who underwent bilateral lung transplantation due to severe respiratory failure with pulmonary hypertension.",

keywords = "Brain-dead donor, Chronic sinusitis, Diffuse panbronchiolitis, Lung transplantation, Pulmonary hypertension",

author = "Yasutaka Onishi and Tetsuji Kawamura and Akie Morimoto and Yasuharu Nakahara and Yoshiro Mochizuki and Kentaroh Miyoshi and Takahiro Oto",

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AU - Onishi, Yasutaka

AU - Kawamura, Tetsuji

AU - Morimoto, Akie

AU - Nakahara, Yasuharu

AU - Mochizuki, Yoshiro

AU - Miyoshi, Kentaroh

AU - Oto, Takahiro

PY - 2015/9/1

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AB - Diffuse panbronchiolitis (DPB) is a chronic respiratory disease that mainly involves the respiratory bronchioles, and has historically been associated with a very poor prognosis. The development of long-term low dose macrolide therapy in the 1980s has dramatically improved the prognosis of DPB. Nevertheless, some cases are resistant to macrolide therapy, and ultimately develop severe respiratory failure and pulmonary hypertension; in such cases lung transplantation is a viable treatment option. Here we report the case of a 40-year-old patient with a 20-year history of DPB, who underwent bilateral lung transplantation due to severe respiratory failure with pulmonary hypertension.

KW - Brain-dead donor

KW - Chronic sinusitis

KW - Diffuse panbronchiolitis

KW - Lung transplantation

KW - Pulmonary hypertension

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A case of diffuse panbronchiolitis, associated with severe pulmonary hypertension, managed with bilateral lung transplantation from a brain-dead donor

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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