TY - JOUR
T1 - A case of elderly-onset type 1 diabetes with first-degree family history with negative GAD antibody and positive IA-2 antibody
AU - Asano, Michiko
AU - Tone, Atsuhito
AU - Katayama, Akihiro
AU - Furujo, Mahoko
AU - Higuchi, Chigusa
AU - Tsukamoto, Keiko
AU - Iseda, Izumi
AU - Hida, Kazuyuki
AU - Uesu, Tokurou
AU - Shikata, Kenichi
PY - 2010/3
Y1 - 2010/3
N2 - A 50-year-old man, whose second of two daughters was treated for type 1 diabetes, seen for polyuria and weight loss in August 2008 had been found to have HbA1C of 6.2% in an annual physical cheakup in April 2008. He was hospitalized for markedly elevated HbA1C of 10.3% and plasma glucose of 463 mg/d/ detected in a blood test Laboratory studies showed a urinary CPR concentration of 21.9 μg/day and serum CPR of 0.2 ng/m/ before and 0.4 ng/m/ 6 minutes after glucagon administration, indicating decreased insulin secretion. Intensive insulin therapy was initiated. Although GAD antibody was negative, IA-2 antibody was positive (9.1 U/ml), leading to a diagnosis of type 1 diabetes mellitus. HLA typing was DRB1* 010101 and 090102, type 1 diabetes-susceptibility gene, identical to the typing of his second daughter. This case of elderly-onset of type 1 diabetes is interesting, manifesting negative GAD antibody and positive IA-2 antibody, especially with a family history of type 1 diabetes.
AB - A 50-year-old man, whose second of two daughters was treated for type 1 diabetes, seen for polyuria and weight loss in August 2008 had been found to have HbA1C of 6.2% in an annual physical cheakup in April 2008. He was hospitalized for markedly elevated HbA1C of 10.3% and plasma glucose of 463 mg/d/ detected in a blood test Laboratory studies showed a urinary CPR concentration of 21.9 μg/day and serum CPR of 0.2 ng/m/ before and 0.4 ng/m/ 6 minutes after glucagon administration, indicating decreased insulin secretion. Intensive insulin therapy was initiated. Although GAD antibody was negative, IA-2 antibody was positive (9.1 U/ml), leading to a diagnosis of type 1 diabetes mellitus. HLA typing was DRB1* 010101 and 090102, type 1 diabetes-susceptibility gene, identical to the typing of his second daughter. This case of elderly-onset of type 1 diabetes is interesting, manifesting negative GAD antibody and positive IA-2 antibody, especially with a family history of type 1 diabetes.
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M3 - Article
AN - SCOPUS:77952045238
SN - 0021-437X
VL - 53
SP - 174
EP - 179
JO - Journal of the Japan Diabetes Society
JF - Journal of the Japan Diabetes Society
IS - 3
ER -
