TY - JOUR
T1 - A case of enterochromaffin-like cell neuroendocrine tumor associated with parietal cell dysfunction which was successfully treated with somatostatin analogue
AU - Hirai, Ryosuke
AU - Haruma, Ken
AU - Okada, Hiroyuki
AU - Itakura, Junya
AU - Mizuno, Motowo
N1 - Funding Information:
We thank Drs. Mitsuaki Ishioka and Hiroshi Kawachi (Department of Gastroenterology and Department of Pathology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Toyo, Japan) for their helpful comments on the immunohistochemistry of H+/K+-ATPase.
Publisher Copyright:
© 2022, Japanese Society of Gastroenterology.
PY - 2022/4
Y1 - 2022/4
N2 - We report here a case of a 62-year-old woman with multiple gastric enterochromaffin-like cell neuroendocrine tumor caused by hypergastrinemia due to parietal cell dysfunction that was successfully treated with somatostatin analogue. Esophagogastroduodenoscopy revealed several G1 neuroendocrine tumors, 10 mm in diameter, in the body of the stomach. No evidence of autoimmune gastritis, Helicobacter pylori infection, neuroendocrine neoplasia type 1, or Zollinger–Ellison syndrome was identified. The pattern of immunohistochemical staining of the background gastric mucosa was suggestive of parietal cell dysfunction. She was treated with long-acting release octreotide acetate. Complete response was confirmed after 9 months and was maintained for 22 months.
AB - We report here a case of a 62-year-old woman with multiple gastric enterochromaffin-like cell neuroendocrine tumor caused by hypergastrinemia due to parietal cell dysfunction that was successfully treated with somatostatin analogue. Esophagogastroduodenoscopy revealed several G1 neuroendocrine tumors, 10 mm in diameter, in the body of the stomach. No evidence of autoimmune gastritis, Helicobacter pylori infection, neuroendocrine neoplasia type 1, or Zollinger–Ellison syndrome was identified. The pattern of immunohistochemical staining of the background gastric mucosa was suggestive of parietal cell dysfunction. She was treated with long-acting release octreotide acetate. Complete response was confirmed after 9 months and was maintained for 22 months.
KW - Enterochromaffin-like cell neuroendocrine tumor
KW - Hypergastrinemia
KW - Parietal cell dysfunction
KW - Somatostatin analogue
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U2 - 10.1007/s12328-021-01581-6
DO - 10.1007/s12328-021-01581-6
M3 - Article
C2 - 34982362
AN - SCOPUS:85122252728
SN - 1865-7257
VL - 15
SP - 363
EP - 367
JO - Clinical Journal of Gastroenterology
JF - Clinical Journal of Gastroenterology
IS - 2
ER -