A case of hemoglobin Hiroshima (β146 histidine to aspartic acid) with compensatory erythremia and undetectable HbA 1c

Hisakazu Nishimori; Keiko Harano; Hideho Wada; Satoshi Takano; Shinji Fukuda; Yukihito Takehara; Hiroshi Matsumoto; Isao Kumagai; Mitsune Tanimoto; Sho Takeda

doi:10.1007/s12185-012-1066-1

A case of hemoglobin Hiroshima (β146 histidine to aspartic acid) with compensatory erythremia and undetectable HbA _1c

Hisakazu Nishimori, Keiko Harano, Hideho Wada, Satoshi Takano, Shinji Fukuda, Yukihito Takehara, Hiroshi Matsumoto, Isao Kumagai, Mitsune Tanimoto, Sho Takeda

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Hemoglobin (Hb) Hiroshima is an Hb variant that travels rapidly on electrophoresis and shows a fourfold increase in oxygen affinity and a decreased Bohr effect. We encountered a 40-year-old male patient with erythremia and an undetectable HbA _1c level. The presence of an abnormal hemoglobin molecule was suggested by the results of high-performance liquid chromatography analysis. Subsequent gene analysis by direct sequencing confirmed Hb Hiroshima (β146 histidine → aspartic acid). Caution should be exercised when diagnosing erythremia.

Original language	English
Pages (from-to)	697-701
Number of pages	5
Journal	International journal of hematology
Volume	95
Issue number	6
DOIs	https://doi.org/10.1007/s12185-012-1066-1
Publication status	Published - Jun 2012

Keywords

Abnormal hemoglobin
Erythropoietin
HbA
Hemoglobin Hiroshima
Hemoglobin variant

ASJC Scopus subject areas

Hematology

Access to Document

10.1007/s12185-012-1066-1

Cite this

@article{d3e062721cab466581b8535593789f10,

title = "A case of hemoglobin Hiroshima (β146 histidine to aspartic acid) with compensatory erythremia and undetectable HbA 1c ",

abstract = "Hemoglobin (Hb) Hiroshima is an Hb variant that travels rapidly on electrophoresis and shows a fourfold increase in oxygen affinity and a decreased Bohr effect. We encountered a 40-year-old male patient with erythremia and an undetectable HbA 1c level. The presence of an abnormal hemoglobin molecule was suggested by the results of high-performance liquid chromatography analysis. Subsequent gene analysis by direct sequencing confirmed Hb Hiroshima (β146 histidine → aspartic acid). Caution should be exercised when diagnosing erythremia.",

keywords = "Abnormal hemoglobin, Erythropoietin, HbA, Hemoglobin Hiroshima, Hemoglobin variant",

author = "Hisakazu Nishimori and Keiko Harano and Hideho Wada and Satoshi Takano and Shinji Fukuda and Yukihito Takehara and Hiroshi Matsumoto and Isao Kumagai and Mitsune Tanimoto and Sho Takeda",

year = "2012",

month = jun,

doi = "10.1007/s12185-012-1066-1",

language = "English",

volume = "95",

pages = "697--701",

journal = "International journal of hematology",

issn = "0925-5710",

publisher = "Springer Japan",

number = "6",

}

TY - JOUR

T1 - A case of hemoglobin Hiroshima (β146 histidine to aspartic acid) with compensatory erythremia and undetectable HbA 1c

AU - Nishimori, Hisakazu

AU - Harano, Keiko

AU - Wada, Hideho

AU - Takano, Satoshi

AU - Fukuda, Shinji

AU - Takehara, Yukihito

AU - Matsumoto, Hiroshi

AU - Kumagai, Isao

AU - Tanimoto, Mitsune

AU - Takeda, Sho

PY - 2012/6

Y1 - 2012/6

N2 - Hemoglobin (Hb) Hiroshima is an Hb variant that travels rapidly on electrophoresis and shows a fourfold increase in oxygen affinity and a decreased Bohr effect. We encountered a 40-year-old male patient with erythremia and an undetectable HbA 1c level. The presence of an abnormal hemoglobin molecule was suggested by the results of high-performance liquid chromatography analysis. Subsequent gene analysis by direct sequencing confirmed Hb Hiroshima (β146 histidine → aspartic acid). Caution should be exercised when diagnosing erythremia.

AB - Hemoglobin (Hb) Hiroshima is an Hb variant that travels rapidly on electrophoresis and shows a fourfold increase in oxygen affinity and a decreased Bohr effect. We encountered a 40-year-old male patient with erythremia and an undetectable HbA 1c level. The presence of an abnormal hemoglobin molecule was suggested by the results of high-performance liquid chromatography analysis. Subsequent gene analysis by direct sequencing confirmed Hb Hiroshima (β146 histidine → aspartic acid). Caution should be exercised when diagnosing erythremia.

KW - Abnormal hemoglobin

KW - Erythropoietin

KW - HbA

KW - Hemoglobin Hiroshima

KW - Hemoglobin variant

UR - http://www.scopus.com/inward/record.url?scp=84865039271&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865039271&partnerID=8YFLogxK

U2 - 10.1007/s12185-012-1066-1

DO - 10.1007/s12185-012-1066-1

M3 - Article

C2 - 22484594

AN - SCOPUS:84865039271

SN - 0925-5710

VL - 95

SP - 697

EP - 701

JO - International journal of hematology

JF - International journal of hematology

IS - 6

ER -