A case of invasive fungal sphenoiditis treated by sphenoid drill-out

Seiichiro Makihara, Mitsuhiro Okano, Hisashi Ishihara, Tomomi Miyatake, Munechika Tsumura, Shin Kariya, Kazunori Nishizaki

Research output: Contribution to journalArticlepeer-review


We present a 68-year-old man suffered from invasive fungal sphenoiditis. The patient complained of right eye pain and headache. His sphenoiditis was refractory to both medical management of VRCZ and sphenoidotomy, and finally he underwent sphenoid drill-out. After the final surgery, we performed therapeutic drug monitoring (TDM) and managed the internal use of VRCZ thoroughly. After a year, he has been doing well. When the clinical response is poor, or side effects are developed, measurement of the TDM is important as a tool of medical management.

Original languageEnglish
Pages (from-to)765-770
Number of pages6
JournalOtolaryngology - Head and Neck Surgery (Japan)
Issue number9
Publication statusPublished - Aug 2014
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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