A case of squamous cell carcinoma ex pleomorphic adenoma in the palate: Immunohistochemical analysis and chromosomal alteration by comparative genomic hybridization

Masamichi Ita; Kenichiro Utida; Hitoshi Nagatsuka; Toshikazu Gondo; Kohsuke Sasaki; Yoshiya Ueyama

doi:10.1016/j.ooe.2005.04.004

A case of squamous cell carcinoma ex pleomorphic adenoma in the palate: Immunohistochemical analysis and chromosomal alteration by comparative genomic hybridization

Masamichi Ita, Kenichiro Utida, Hitoshi Nagatsuka, Toshikazu Gondo, Kohsuke Sasaki, Yoshiya Ueyama

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Carcinoma ex pleomorphic adenoma (CXPA) is an uncommon tumor of salivary gland; moreover, histologically, squamous cell carcinoma (SCC) is exceedingly rare. This report documents a case of CXPA arising in the hard palate, which showed transformation from pleomorphic adenoma (PA) to SCC reacted to Ki-67 immunostaining. Other immunohistochemical stains also demonstrated different immunoreactivities between PA cells and SCC cells. Comparative genomic hybridization identified a chromosomal imbalance. Gain regions of the PA were 8q11-22 and 8q24 and the loss region was 13q32-34 in PA; additionally, in SCC, regions characterized by increased DNA copy number were 8p, 8q and 12q12-15.

Original language	English
Pages (from-to)	170-173
Number of pages	4
Journal	Oral Oncology Extra
Volume	41
Issue number	8
DOIs	https://doi.org/10.1016/j.ooe.2005.04.004
Publication status	Published - Sept 2005

Keywords

CXPA
Comparative genomic hybridization
Hard palate
Immunostain
Malignant transformation
Squamous cell carcinoma

ASJC Scopus subject areas

Oral Surgery
Pathology and Forensic Medicine
Otorhinolaryngology
Oncology

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10.1016/j.ooe.2005.04.004

Cite this

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title = "A case of squamous cell carcinoma ex pleomorphic adenoma in the palate: Immunohistochemical analysis and chromosomal alteration by comparative genomic hybridization",

abstract = "Carcinoma ex pleomorphic adenoma (CXPA) is an uncommon tumor of salivary gland; moreover, histologically, squamous cell carcinoma (SCC) is exceedingly rare. This report documents a case of CXPA arising in the hard palate, which showed transformation from pleomorphic adenoma (PA) to SCC reacted to Ki-67 immunostaining. Other immunohistochemical stains also demonstrated different immunoreactivities between PA cells and SCC cells. Comparative genomic hybridization identified a chromosomal imbalance. Gain regions of the PA were 8q11-22 and 8q24 and the loss region was 13q32-34 in PA; additionally, in SCC, regions characterized by increased DNA copy number were 8p, 8q and 12q12-15.",

keywords = "CXPA, Comparative genomic hybridization, Hard palate, Immunostain, Malignant transformation, Squamous cell carcinoma",

author = "Masamichi Ita and Kenichiro Utida and Hitoshi Nagatsuka and Toshikazu Gondo and Kohsuke Sasaki and Yoshiya Ueyama",

year = "2005",

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T1 - A case of squamous cell carcinoma ex pleomorphic adenoma in the palate

T2 - Immunohistochemical analysis and chromosomal alteration by comparative genomic hybridization

AU - Ita, Masamichi

AU - Utida, Kenichiro

AU - Nagatsuka, Hitoshi

AU - Gondo, Toshikazu

AU - Sasaki, Kohsuke

AU - Ueyama, Yoshiya

PY - 2005/9

Y1 - 2005/9

N2 - Carcinoma ex pleomorphic adenoma (CXPA) is an uncommon tumor of salivary gland; moreover, histologically, squamous cell carcinoma (SCC) is exceedingly rare. This report documents a case of CXPA arising in the hard palate, which showed transformation from pleomorphic adenoma (PA) to SCC reacted to Ki-67 immunostaining. Other immunohistochemical stains also demonstrated different immunoreactivities between PA cells and SCC cells. Comparative genomic hybridization identified a chromosomal imbalance. Gain regions of the PA were 8q11-22 and 8q24 and the loss region was 13q32-34 in PA; additionally, in SCC, regions characterized by increased DNA copy number were 8p, 8q and 12q12-15.

AB - Carcinoma ex pleomorphic adenoma (CXPA) is an uncommon tumor of salivary gland; moreover, histologically, squamous cell carcinoma (SCC) is exceedingly rare. This report documents a case of CXPA arising in the hard palate, which showed transformation from pleomorphic adenoma (PA) to SCC reacted to Ki-67 immunostaining. Other immunohistochemical stains also demonstrated different immunoreactivities between PA cells and SCC cells. Comparative genomic hybridization identified a chromosomal imbalance. Gain regions of the PA were 8q11-22 and 8q24 and the loss region was 13q32-34 in PA; additionally, in SCC, regions characterized by increased DNA copy number were 8p, 8q and 12q12-15.

KW - CXPA

KW - Comparative genomic hybridization

KW - Hard palate

KW - Immunostain

KW - Malignant transformation

KW - Squamous cell carcinoma

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A case of squamous cell carcinoma ex pleomorphic adenoma in the palate: Immunohistochemical analysis and chromosomal alteration by comparative genomic hybridization

Abstract

Keywords

ASJC Scopus subject areas

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