A case of type 2 diabetes and metastatic liver cancer exhibiting hypercholesterolemia with abnormal lipoproteins

Motoko Kanzaki; Jun Wada; Atsuko Nakatsuka; Sanae Teshigawara; Kazutoshi Murakami; Kentaro Inoue; Takahiro Terami; Akihiro Katayama; Junichiro Nasu; Kazuhide Yamamoto; Hirofumi Makino

doi:10.2169/internalmedicine.51.6486

A case of type 2 diabetes and metastatic liver cancer exhibiting hypercholesterolemia with abnormal lipoproteins

Motoko Kanzaki, Jun Wada, Atsuko Nakatsuka, Sanae Teshigawara, Kazutoshi Murakami, Kentaro Inoue, Takahiro Terami, Akihiro Katayama, Junichiro Nasu, Kazuhide Yamamoto, Hirofumi Makino

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Although the appearance of abnormal lipoproteins in liver diseases is well known, the precise analyses of abnormal lipoproteins remain elusive. Here, we report a 71-year-old woman with type 2 diabetes whose serum cholesterol levels were elevated to 560 mg/dL over a 4-month period. High-performance liquid chromatography demonstrated the presence of lipoprotein-X and lipoprotein-Y and sigmoid colon cancer and multiple liver metastases were found by colonoscopy and computed tomography. Remission of the primary colon cancer and liver lesions was achieved by chemotherapy with oxaliplatin and fluorouracil and her serum cholesterol went back to basal levels associated with the disappearance of abnormal lipoproteins.

Original language	English
Pages (from-to)	619-623
Number of pages	5
Journal	Internal Medicine
Volume	51
Issue number	6
DOIs	https://doi.org/10.2169/internalmedicine.51.6486
Publication status	Published - 2012

Keywords

HPLC
Hypercholesterolemia
Lipoprotein-X
Lipoprotein-Y

ASJC Scopus subject areas

Internal Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2169/internalmedicine.51.6486

Cite this

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abstract = "Although the appearance of abnormal lipoproteins in liver diseases is well known, the precise analyses of abnormal lipoproteins remain elusive. Here, we report a 71-year-old woman with type 2 diabetes whose serum cholesterol levels were elevated to 560 mg/dL over a 4-month period. High-performance liquid chromatography demonstrated the presence of lipoprotein-X and lipoprotein-Y and sigmoid colon cancer and multiple liver metastases were found by colonoscopy and computed tomography. Remission of the primary colon cancer and liver lesions was achieved by chemotherapy with oxaliplatin and fluorouracil and her serum cholesterol went back to basal levels associated with the disappearance of abnormal lipoproteins.",

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AU - Kanzaki, Motoko

AU - Wada, Jun

AU - Nakatsuka, Atsuko

AU - Teshigawara, Sanae

AU - Murakami, Kazutoshi

AU - Inoue, Kentaro

AU - Terami, Takahiro

AU - Katayama, Akihiro

AU - Nasu, Junichiro

AU - Yamamoto, Kazuhide

AU - Makino, Hirofumi

PY - 2012

Y1 - 2012

N2 - Although the appearance of abnormal lipoproteins in liver diseases is well known, the precise analyses of abnormal lipoproteins remain elusive. Here, we report a 71-year-old woman with type 2 diabetes whose serum cholesterol levels were elevated to 560 mg/dL over a 4-month period. High-performance liquid chromatography demonstrated the presence of lipoprotein-X and lipoprotein-Y and sigmoid colon cancer and multiple liver metastases were found by colonoscopy and computed tomography. Remission of the primary colon cancer and liver lesions was achieved by chemotherapy with oxaliplatin and fluorouracil and her serum cholesterol went back to basal levels associated with the disappearance of abnormal lipoproteins.

AB - Although the appearance of abnormal lipoproteins in liver diseases is well known, the precise analyses of abnormal lipoproteins remain elusive. Here, we report a 71-year-old woman with type 2 diabetes whose serum cholesterol levels were elevated to 560 mg/dL over a 4-month period. High-performance liquid chromatography demonstrated the presence of lipoprotein-X and lipoprotein-Y and sigmoid colon cancer and multiple liver metastases were found by colonoscopy and computed tomography. Remission of the primary colon cancer and liver lesions was achieved by chemotherapy with oxaliplatin and fluorouracil and her serum cholesterol went back to basal levels associated with the disappearance of abnormal lipoproteins.

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KW - Hypercholesterolemia

KW - Lipoprotein-X

KW - Lipoprotein-Y

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A case of type 2 diabetes and metastatic liver cancer exhibiting hypercholesterolemia with abnormal lipoproteins

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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