A Case Report of Middle-aged Women with Solid and Cystic Tumor of the Pancreas

Nobuji Yokoyama; Kunihiro Kawashima; Keiji Kino; Shinpei Takeda; Kenjiro Aogi; Hiroyoshi Doihara; Minora Tanada; Hiroyuki Soga; Hajime Kurita; Wataru Takiyama; Hideyuki Saeki; Shigemitsu Takashima; Kouichi Mandai; Shosuke Moriwaki

doi:10.5833/jjgs.24.910

A Case Report of Middle-aged Women with Solid and Cystic Tumor of the Pancreas

Nobuji Yokoyama, Kunihiro Kawashima, Keiji Kino, Shinpei Takeda, Kenjiro Aogi, Hiroyoshi Doihara, Minora Tanada, Hiroyuki Soga, Hajime Kurita, Wataru Takiyama, Hideyuki Saeki, Shigemitsu Takashima, Kouichi Mandai, Shosuke Moriwaki

Research output: Contribution to journal › Article › peer-review

Abstract

Solid and cystic tumor of the pancreas is a rare low-grade malignant tumor occurring chiefly in young women. We report the case of a 49-year-old woman who received a pancreatoduodenectomy for a tumor in the uncal region of the pancreas. The tumor mass was 7 X 5 X 5 cm in diameter and well encapsulated. The cut surface showed extensive necrosis and hemorrhage except for some solid areas along the inside of the capsule. Histologically, sheets of tumor cells surrounding thin-walled vessels containing erythrocytes were predominant with some oval cells arranged about a fibrovascular stalk or a small blood vessel and focal invasions of the fibrous capsule. In addition, most tumor cells negative for Grimelius stain were immunohistochemically positive for α_rantitrypsin and showed no immunoreactivity with insulin, glucagon, estrogen receptor or progesterone receptor. These findings suggest that the tumor cells were capable of differentiation to acinar cells and had malignant potentiality.

Original language	English
Pages (from-to)	910-914
Number of pages	5
Journal	Japanese Journal of Gastroenterological Surgery
Volume	24
Issue number	3
DOIs	https://doi.org/10.5833/jjgs.24.910
Publication status	Published - Feb 1 1991
Externally published	Yes

Keywords

estrogen receptor
progesterone receptor
solid and cystic tumor of the pancreas

ASJC Scopus subject areas

Surgery
Gastroenterology

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title = "A Case Report of Middle-aged Women with Solid and Cystic Tumor of the Pancreas",

abstract = "Solid and cystic tumor of the pancreas is a rare low-grade malignant tumor occurring chiefly in young women. We report the case of a 49-year-old woman who received a pancreatoduodenectomy for a tumor in the uncal region of the pancreas. The tumor mass was 7 X 5 X 5 cm in diameter and well encapsulated. The cut surface showed extensive necrosis and hemorrhage except for some solid areas along the inside of the capsule. Histologically, sheets of tumor cells surrounding thin-walled vessels containing erythrocytes were predominant with some oval cells arranged about a fibrovascular stalk or a small blood vessel and focal invasions of the fibrous capsule. In addition, most tumor cells negative for Grimelius stain were immunohistochemically positive for αrantitrypsin and showed no immunoreactivity with insulin, glucagon, estrogen receptor or progesterone receptor. These findings suggest that the tumor cells were capable of differentiation to acinar cells and had malignant potentiality.",

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AU - Yokoyama, Nobuji

AU - Kawashima, Kunihiro

AU - Kino, Keiji

AU - Takeda, Shinpei

AU - Aogi, Kenjiro

AU - Doihara, Hiroyoshi

AU - Tanada, Minora

AU - Soga, Hiroyuki

AU - Kurita, Hajime

AU - Takiyama, Wataru

AU - Saeki, Hideyuki

AU - Takashima, Shigemitsu

AU - Mandai, Kouichi

AU - Moriwaki, Shosuke

PY - 1991/2/1

Y1 - 1991/2/1

N2 - Solid and cystic tumor of the pancreas is a rare low-grade malignant tumor occurring chiefly in young women. We report the case of a 49-year-old woman who received a pancreatoduodenectomy for a tumor in the uncal region of the pancreas. The tumor mass was 7 X 5 X 5 cm in diameter and well encapsulated. The cut surface showed extensive necrosis and hemorrhage except for some solid areas along the inside of the capsule. Histologically, sheets of tumor cells surrounding thin-walled vessels containing erythrocytes were predominant with some oval cells arranged about a fibrovascular stalk or a small blood vessel and focal invasions of the fibrous capsule. In addition, most tumor cells negative for Grimelius stain were immunohistochemically positive for αrantitrypsin and showed no immunoreactivity with insulin, glucagon, estrogen receptor or progesterone receptor. These findings suggest that the tumor cells were capable of differentiation to acinar cells and had malignant potentiality.

AB - Solid and cystic tumor of the pancreas is a rare low-grade malignant tumor occurring chiefly in young women. We report the case of a 49-year-old woman who received a pancreatoduodenectomy for a tumor in the uncal region of the pancreas. The tumor mass was 7 X 5 X 5 cm in diameter and well encapsulated. The cut surface showed extensive necrosis and hemorrhage except for some solid areas along the inside of the capsule. Histologically, sheets of tumor cells surrounding thin-walled vessels containing erythrocytes were predominant with some oval cells arranged about a fibrovascular stalk or a small blood vessel and focal invasions of the fibrous capsule. In addition, most tumor cells negative for Grimelius stain were immunohistochemically positive for αrantitrypsin and showed no immunoreactivity with insulin, glucagon, estrogen receptor or progesterone receptor. These findings suggest that the tumor cells were capable of differentiation to acinar cells and had malignant potentiality.

KW - estrogen receptor

KW - progesterone receptor

KW - solid and cystic tumor of the pancreas

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A Case Report of Middle-aged Women with Solid and Cystic Tumor of the Pancreas

Abstract

Keywords

ASJC Scopus subject areas

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