A clinical study of endoscopic local coagulation therapy for hepatocellular carcinoma (HCC)

Shigehiro Shiozaki, Masashi Nishitani, Eiji Yamada, Hisami Okusha, Takahiro Mimae, Takaoki Furukawa, Akito Morita, Youji Kubo, Yasuhiro Choda, Masahiko Nishizaki, Masao Harano, Hideki Aoki, Tadashi Onoda, Satoshi Ohno, Motoki Ninomiya, Norihisa Takakura

Research output: Contribution to journalArticlepeer-review


Eighteen subjects with cases of HCC who underwent endoscopic local coagulation therapy at Hiroshima City Hospital between 1998 and 2004 were studied and compared with 6 cases of HCC patients who underwent laparoscopic partial hepatectomy during the same period. The subjects composed of 10 cases of laparoscopic microwave coagulation therapy (L-MCT), 5 cases of laparoscopic radio frequency ablation therapy (L-RFA), and 3 cases of thoracoscopic microwave coagulation therapy (T-MCT). The operation time was 114 minutes for L-MCT and 92 minutes for L-RFA, both of which were significantly shorter than 208 minutes for resection cases. No complications were developed in any of the cases and the postoperative hospitalization period of the cases was 13.1 days, 8.2 days, and 13.0 days, respectively. Although each case of local recurrence was observed both in L-MCT and L-RFA groups, one case displayed observation difficulty from the liver surface and the other required a daughter nodule. The three-year survival rate was 71.4%, while the five-year survival rate was 53.6%. Endoscopic local coagulation therapy is not too invasive and useful for hepatocellular carcinoma in which percutaneous RFA is difficult. However, it is well indicated when the scope is evident with observation being feasible from the liver surface.

Original languageEnglish
Pages (from-to)1603-1605
Number of pages3
JournalGan to kagaku ryoho. Cancer & chemotherapy
Issue number11
Publication statusPublished - Oct 2005
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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