A Clinical Trial Evaluating the Usefulness of Tailored Antimicrobial Prophylaxis Using Rectal-culture Screening Media Prior to Transrectal Prostate Biopsy: A Multicenter, Randomized Controlled Trial

Takuya Sadahira; Yuki Maruyama; Yoshiki Hiyama; Hiroyuki Kitano; Hiroki Yamada; Takayuki Goto; Tsubasa Kondo; Katsumi Shigemura; Yosuke Mitsui; Takehiro Iwata; Kohei Edamura; Motoo Araki; Masami Watanabe; Tadasu Takenaka; Jun Teishima; Yasuyoshi Miyata; Kiyohito Ishikawa; Ei Ichiro Takaoka; Jun Miyazaki; Satoshi Takahashi; Naoya Masumori; Hiroshi Kiyota; Masato Fujisawa; Shingo Yamamoto; Takafumi Sakuma; Norihiro Kusumi; Takaharu Ichikawa; Toyohiko Watanabe; Yoshitsugu Nasu; Masaya Tsugawa; Yasutomo Nasu; Koichiro Wada

A Clinical Trial Evaluating the Usefulness of Tailored Antimicrobial Prophylaxis Using Rectal-culture Screening Media Prior to Transrectal Prostate Biopsy: A Multicenter, Randomized Controlled Trial

Takuya Sadahira, Yuki Maruyama, Yoshiki Hiyama, Hiroyuki Kitano, Hiroki Yamada, Takayuki Goto, Tsubasa Kondo, Katsumi Shigemura, Yosuke Mitsui, Takehiro Iwata, Kohei Edamura, Motoo Araki, Masami Watanabe, Tadasu Takenaka, Jun Teishima, Yasuyoshi Miyata, Kiyohito Ishikawa, Ei Ichiro Takaoka, Jun Miyazaki, Satoshi TakahashiNaoya Masumori, Hiroshi Kiyota, Masato Fujisawa, Shingo Yamamoto, Takafumi Sakuma, Norihiro Kusumi, Takaharu Ichikawa, Toyohiko Watanabe, Yoshitsugu Nasu, Masaya Tsugawa, Yasutomo Nasu, Koichiro Wada

Research output: Contribution to journal › Article › peer-review

Abstract

The aim of this report is to introduce an on-going, multicenter, randomized controlled trial to evaluate whether tailored antimicrobial prophylaxis guided by rectal culture screening prevents acute bacterial prostatitis following transrectal prostate biopsy (TRPB). Patients will be randomized into an intervention or non-intervention group; tazobactam-piperacillin or levofloxacin will be prophylactically administered according to the results of rectal culture prior to TRPB in the intervention group whereas levofloxacin will be routinely given in the non-intervention group. The primary endpoint is the occurrence rate of acute bacterial prostatitis after TRPB. Recruitment begins in April, 2021 and the target total sample size is 5,100 participants.

Original language	English
Pages (from-to)	663-667
Number of pages	5
Journal	Acta medica Okayama
Volume	75
Issue number	5
Publication status	Published - 2021

Keywords

antibiotic prophylaxis
extended-spectrum beta-lactamase
fluoroquinolone-resistant
prostate biopsy
selective culture media

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Cite this

Sadahira, T., Maruyama, Y., Hiyama, Y., Kitano, H., Yamada, H., Goto, T., Kondo, T., Shigemura, K., Mitsui, Y., Iwata, T., Edamura, K., Araki, M., Watanabe, M., Takenaka, T., Teishima, J., Miyata, Y., Ishikawa, K., Takaoka, E. I., Miyazaki, J., ... Wada, K. (2021). A Clinical Trial Evaluating the Usefulness of Tailored Antimicrobial Prophylaxis Using Rectal-culture Screening Media Prior to Transrectal Prostate Biopsy: A Multicenter, Randomized Controlled Trial. Acta medica Okayama, 75(5), 663-667.

A Clinical Trial Evaluating the Usefulness of Tailored Antimicrobial Prophylaxis Using Rectal-culture Screening Media Prior to Transrectal Prostate Biopsy: A Multicenter, Randomized Controlled Trial. / Sadahira, Takuya ; Maruyama, Yuki; Hiyama, Yoshiki et al.
In: Acta medica Okayama, Vol. 75, No. 5, 2021, p. 663-667.

Research output: Contribution to journal › Article › peer-review

Sadahira, T , Maruyama, Y, Hiyama, Y, Kitano, H, Yamada, H, Goto, T, Kondo, T, Shigemura, K, Mitsui, Y, Iwata, T , Edamura, K , Araki, M , Watanabe, M, Takenaka, T, Teishima, J, Miyata, Y, Ishikawa, K, Takaoka, EI, Miyazaki, J, Takahashi, S, Masumori, N, Kiyota, H, Fujisawa, M, Yamamoto, S, Sakuma, T, Kusumi, N, Ichikawa, T, Watanabe, T, Nasu, Y, Tsugawa, M, Nasu, Y & Wada, K 2021, 'A Clinical Trial Evaluating the Usefulness of Tailored Antimicrobial Prophylaxis Using Rectal-culture Screening Media Prior to Transrectal Prostate Biopsy: A Multicenter, Randomized Controlled Trial', Acta medica Okayama, vol. 75, no. 5, pp. 663-667.

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title = "A Clinical Trial Evaluating the Usefulness of Tailored Antimicrobial Prophylaxis Using Rectal-culture Screening Media Prior to Transrectal Prostate Biopsy: A Multicenter, Randomized Controlled Trial",

abstract = "The aim of this report is to introduce an on-going, multicenter, randomized controlled trial to evaluate whether tailored antimicrobial prophylaxis guided by rectal culture screening prevents acute bacterial prostatitis following transrectal prostate biopsy (TRPB). Patients will be randomized into an intervention or non-intervention group; tazobactam-piperacillin or levofloxacin will be prophylactically administered according to the results of rectal culture prior to TRPB in the intervention group whereas levofloxacin will be routinely given in the non-intervention group. The primary endpoint is the occurrence rate of acute bacterial prostatitis after TRPB. Recruitment begins in April, 2021 and the target total sample size is 5,100 participants.",

keywords = "antibiotic prophylaxis, extended-spectrum beta-lactamase, fluoroquinolone-resistant, prostate biopsy, selective culture media",

author = "Takuya Sadahira and Yuki Maruyama and Yoshiki Hiyama and Hiroyuki Kitano and Hiroki Yamada and Takayuki Goto and Tsubasa Kondo and Katsumi Shigemura and Yosuke Mitsui and Takehiro Iwata and Kohei Edamura and Motoo Araki and Masami Watanabe and Tadasu Takenaka and Jun Teishima and Yasuyoshi Miyata and Kiyohito Ishikawa and Takaoka, {Ei Ichiro} and Jun Miyazaki and Satoshi Takahashi and Naoya Masumori and Hiroshi Kiyota and Masato Fujisawa and Shingo Yamamoto and Takafumi Sakuma and Norihiro Kusumi and Takaharu Ichikawa and Toyohiko Watanabe and Yoshitsugu Nasu and Masaya Tsugawa and Yasutomo Nasu and Koichiro Wada",

note = "Funding Information: Received January 4, 2021; accepted March 23, 2021. ＊Corresponding author. Phone : +81-86-223-7287; Fax : +81-86-231-3986 E-mail : gmd17055@s.okadai.jp (K. Wada) Conflict of Interest Statement: S Takahashi received speaker honoraria from MSD K. K., a commission fee from the Nippon Professional Baseball Organization and Japan Professional Football League, research grants from Abbott Japan Co., Ltd. and Roche Diagnostics Co., Ltd., and a scholarship contribution from Shino-Test Corporation Co., Ltd. Publisher Copyright: {\textcopyright} 2021. by Okayama University Medical School.",

year = "2021",

language = "English",

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journal = "Acta medica Okayama",

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AU - Sadahira, Takuya

AU - Maruyama, Yuki

AU - Hiyama, Yoshiki

AU - Kitano, Hiroyuki

AU - Yamada, Hiroki

AU - Goto, Takayuki

AU - Kondo, Tsubasa

AU - Shigemura, Katsumi

AU - Mitsui, Yosuke

AU - Iwata, Takehiro

AU - Edamura, Kohei

AU - Araki, Motoo

AU - Watanabe, Masami

AU - Takenaka, Tadasu

AU - Teishima, Jun

AU - Miyata, Yasuyoshi

AU - Ishikawa, Kiyohito

AU - Takaoka, Ei Ichiro

AU - Miyazaki, Jun

AU - Takahashi, Satoshi

AU - Masumori, Naoya

AU - Kiyota, Hiroshi

AU - Fujisawa, Masato

AU - Yamamoto, Shingo

AU - Sakuma, Takafumi

AU - Kusumi, Norihiro

AU - Ichikawa, Takaharu

AU - Watanabe, Toyohiko

AU - Nasu, Yoshitsugu

AU - Tsugawa, Masaya

AU - Nasu, Yasutomo

AU - Wada, Koichiro

N1 - Funding Information: Received January 4, 2021; accepted March 23, 2021. ＊Corresponding author. Phone : +81-86-223-7287; Fax : +81-86-231-3986 E-mail : gmd17055@s.okadai.jp (K. Wada) Conflict of Interest Statement: S Takahashi received speaker honoraria from MSD K. K., a commission fee from the Nippon Professional Baseball Organization and Japan Professional Football League, research grants from Abbott Japan Co., Ltd. and Roche Diagnostics Co., Ltd., and a scholarship contribution from Shino-Test Corporation Co., Ltd. Publisher Copyright: © 2021. by Okayama University Medical School.

PY - 2021

Y1 - 2021

N2 - The aim of this report is to introduce an on-going, multicenter, randomized controlled trial to evaluate whether tailored antimicrobial prophylaxis guided by rectal culture screening prevents acute bacterial prostatitis following transrectal prostate biopsy (TRPB). Patients will be randomized into an intervention or non-intervention group; tazobactam-piperacillin or levofloxacin will be prophylactically administered according to the results of rectal culture prior to TRPB in the intervention group whereas levofloxacin will be routinely given in the non-intervention group. The primary endpoint is the occurrence rate of acute bacterial prostatitis after TRPB. Recruitment begins in April, 2021 and the target total sample size is 5,100 participants.

AB - The aim of this report is to introduce an on-going, multicenter, randomized controlled trial to evaluate whether tailored antimicrobial prophylaxis guided by rectal culture screening prevents acute bacterial prostatitis following transrectal prostate biopsy (TRPB). Patients will be randomized into an intervention or non-intervention group; tazobactam-piperacillin or levofloxacin will be prophylactically administered according to the results of rectal culture prior to TRPB in the intervention group whereas levofloxacin will be routinely given in the non-intervention group. The primary endpoint is the occurrence rate of acute bacterial prostatitis after TRPB. Recruitment begins in April, 2021 and the target total sample size is 5,100 participants.

KW - antibiotic prophylaxis

KW - extended-spectrum beta-lactamase

KW - fluoroquinolone-resistant

KW - prostate biopsy

KW - selective culture media

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AN - SCOPUS:85118634826

SN - 0386-300X

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JO - Acta medica Okayama

JF - Acta medica Okayama

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ER -

A Clinical Trial Evaluating the Usefulness of Tailored Antimicrobial Prophylaxis Using Rectal-culture Screening Media Prior to Transrectal Prostate Biopsy: A Multicenter, Randomized Controlled Trial

Abstract

Keywords

ASJC Scopus subject areas

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