Abstract
The c-erbB-2 proto-oncogene is a gene that encodes a growth factor receptor-like molecule with tyrosine kinase activity. The purpose of this study was to determine whether c-erbB-2 gene amplification measured by the simple and sensitive differential polymerase chain reaction (PCR) method correlates with clinicopathological factors in endometrial adenocarcinomas. Overall, 7 out of the 38 endometrial adenocarcinomas (18.4%) displayed amplified c-erbB-2 oncogene. No correlation between c-erbB-2 gene amplification and FIGO stage, histologic grade or existence of metastatic disease was found. There was a significant association between c-erbB-2 gene amplification and deep myometrial invasion. In the current study, it has been suggested that c-erbB-2 gene amplification is possibly involved in local progression but is not closely related to the loss of cell differentiation and metastasis.
| Original language | English |
|---|---|
| Pages (from-to) | 90-92 |
| Number of pages | 3 |
| Journal | European Journal of Gynaecological Oncology |
| Volume | 19 |
| Issue number | 1 |
| Publication status | Published - Jan 29 1998 |
Keywords
- Endometrial adenocarcinoma
- Gene amplification
- c-erbB-2
ASJC Scopus subject areas
- Oncology
- Obstetrics and Gynaecology