A definite case of l-carbocisteine-induced pneumonia with CATCH22 syndrome

Kenichiro Kudo, Eiki Ichihara, Akiko Hisamoto, Katsuyuki Hotta, Nobuaki Miyahara, Yasushi Tanimoto, Sadaharu Akagi, Katsuya Kato, Mitsune Tanimoto, Katsuyuki Kiura

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


A 32-year-old male with CATCH22 syndrome presented with a high fever and productive cough after taking drugs for acute bronchitis, including L-carbocisteine. Chest radiography revealed ground-glass opacities in the bilateral lung fields. He had a history of similar pneumonia. Under the assumption of drug-induced pneumonia, or bacterial or viral pneumonia, all drugs including L-carbocisteine were discontinued, and antibiotics were started. A drug-induced lymphocyte stimulation test was positive only for L-carbocisteine. The only drug in common between this and the previous episode of pneumonia was L-carbocisteine. We thus concluded that this was a definite case of L-carbocisteine-induced pneumonia in a patient with CATCH22 syndrome.

Original languageEnglish
Pages (from-to)97-100
Number of pages4
JournalInternal Medicine
Issue number1
Publication statusPublished - 2013


  • CATCH22 syndrome
  • Drug-induced lymphocyte stimu- lation test
  • Drug-induced pneumonia
  • L-carbocisteine

ASJC Scopus subject areas

  • Internal Medicine


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