A direct hepatic osmoreceptive afferent projection from nucleus tractus solitarius to dorsal hypothalamus

Motoi Kobashi; Akira Adachi

doi:10.1016/0361-9230(88)90139-6

A direct hepatic osmoreceptive afferent projection from nucleus tractus solitarius to dorsal hypothalamus

Motoi Kobashi, Akira Adachi

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Thirty units that responded antidromically to electrical stimulation of the zona incerta (ZI) or the dorsal portion of hypothalamus were recorded in the nucleus tractus solitarii (NTS). These units were analyzed in relation to hepatoportal afferent inputs. Electrical stimulation of the hepatic branch of the vagus nerve facilitated six units (facilitatory units) and suppressed 10 units (suppressed units). Effect of the portal infusion of hypertonic saline was examined on six facilitatory and eight suppressed units. One facilitatory unit and one suppressed unit increased their discharge rates in response to portal infusion. Four facilitatory units and one suppressed unit decreased their discharge rates in response to the same stimulation. Increased or decreased discharge rates in response to portal infusion of hypertonic saline were observed in units that responded antidromically to electrical stimulation of the paraventricular hypothalamic nucleus, the lateral hypothalamic area, or the ZI. It is concluded that hepatoportal osmoreceptive signals are conveyed to the hypothalamus or the ZI directly from the NTS.

Original language	English
Pages (from-to)	487-492
Number of pages	6
Journal	Brain Research Bulletin
Volume	20
Issue number	4
DOIs	https://doi.org/10.1016/0361-9230(88)90139-6
Publication status	Published - Apr 1988

Keywords

Hepatic vagus
Hepatoportal osmoreceptor
Hypothalamus
Nucleus tractus solitarius

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0361-9230(88)90139-6

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title = "A direct hepatic osmoreceptive afferent projection from nucleus tractus solitarius to dorsal hypothalamus",

abstract = "Thirty units that responded antidromically to electrical stimulation of the zona incerta (ZI) or the dorsal portion of hypothalamus were recorded in the nucleus tractus solitarii (NTS). These units were analyzed in relation to hepatoportal afferent inputs. Electrical stimulation of the hepatic branch of the vagus nerve facilitated six units (facilitatory units) and suppressed 10 units (suppressed units). Effect of the portal infusion of hypertonic saline was examined on six facilitatory and eight suppressed units. One facilitatory unit and one suppressed unit increased their discharge rates in response to portal infusion. Four facilitatory units and one suppressed unit decreased their discharge rates in response to the same stimulation. Increased or decreased discharge rates in response to portal infusion of hypertonic saline were observed in units that responded antidromically to electrical stimulation of the paraventricular hypothalamic nucleus, the lateral hypothalamic area, or the ZI. It is concluded that hepatoportal osmoreceptive signals are conveyed to the hypothalamus or the ZI directly from the NTS.",

keywords = "Hepatic vagus, Hepatoportal osmoreceptor, Hypothalamus, Nucleus tractus solitarius",

author = "Motoi Kobashi and Akira Adachi",

note = "Funding Information: We are thankf~tllo Dr. .A. Simpsonf or his critical readingo f tflc manuscript. This work was supported by Grant-in-Aid t{\textquoteright}ot Encouragemenot f Young Scientist 6177144a7n d Grant-in-Aid for General Scientific Research 6248037Xf rom the Ministry of Education. Science and Culture of Japan.",

year = "1988",

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doi = "10.1016/0361-9230(88)90139-6",

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AU - Kobashi, Motoi

AU - Adachi, Akira

N1 - Funding Information: We are thankf~tllo Dr. .A. Simpsonf or his critical readingo f tflc manuscript. This work was supported by Grant-in-Aid t’ot Encouragemenot f Young Scientist 6177144a7n d Grant-in-Aid for General Scientific Research 6248037Xf rom the Ministry of Education. Science and Culture of Japan.

PY - 1988/4

Y1 - 1988/4

N2 - Thirty units that responded antidromically to electrical stimulation of the zona incerta (ZI) or the dorsal portion of hypothalamus were recorded in the nucleus tractus solitarii (NTS). These units were analyzed in relation to hepatoportal afferent inputs. Electrical stimulation of the hepatic branch of the vagus nerve facilitated six units (facilitatory units) and suppressed 10 units (suppressed units). Effect of the portal infusion of hypertonic saline was examined on six facilitatory and eight suppressed units. One facilitatory unit and one suppressed unit increased their discharge rates in response to portal infusion. Four facilitatory units and one suppressed unit decreased their discharge rates in response to the same stimulation. Increased or decreased discharge rates in response to portal infusion of hypertonic saline were observed in units that responded antidromically to electrical stimulation of the paraventricular hypothalamic nucleus, the lateral hypothalamic area, or the ZI. It is concluded that hepatoportal osmoreceptive signals are conveyed to the hypothalamus or the ZI directly from the NTS.

AB - Thirty units that responded antidromically to electrical stimulation of the zona incerta (ZI) or the dorsal portion of hypothalamus were recorded in the nucleus tractus solitarii (NTS). These units were analyzed in relation to hepatoportal afferent inputs. Electrical stimulation of the hepatic branch of the vagus nerve facilitated six units (facilitatory units) and suppressed 10 units (suppressed units). Effect of the portal infusion of hypertonic saline was examined on six facilitatory and eight suppressed units. One facilitatory unit and one suppressed unit increased their discharge rates in response to portal infusion. Four facilitatory units and one suppressed unit decreased their discharge rates in response to the same stimulation. Increased or decreased discharge rates in response to portal infusion of hypertonic saline were observed in units that responded antidromically to electrical stimulation of the paraventricular hypothalamic nucleus, the lateral hypothalamic area, or the ZI. It is concluded that hepatoportal osmoreceptive signals are conveyed to the hypothalamus or the ZI directly from the NTS.

KW - Hepatic vagus

KW - Hepatoportal osmoreceptor

KW - Hypothalamus

KW - Nucleus tractus solitarius

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A direct hepatic osmoreceptive afferent projection from nucleus tractus solitarius to dorsal hypothalamus

Abstract

Keywords

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