A dosimetric analysis of intensity-modulated radiation therapy with bone marrow sparing for cervical cancer

Naoya Murakami; Hiroyuki Okamoto; Takahiro Kasamatsu; Kazuma Kobayashi; Ken Harada; Mayuka Kitaguchi; Shuhei Sekii; Kana Takahashi; Kotaro Yoshio; Koji Inaba; Madoka Morota; Minako Sumi; Takafumi Toita; Yoshinori Ito; Jun Itami

A dosimetric analysis of intensity-modulated radiation therapy with bone marrow sparing for cervical cancer

Naoya Murakami, Hiroyuki Okamoto, Takahiro Kasamatsu, Kazuma Kobayashi, Ken Harada, Mayuka Kitaguchi, Shuhei Sekii, Kana Takahashi, Kotaro Yoshio, Koji Inaba, Madoka Morota, Minako Sumi, Takafumi Toita, Yoshinori Ito, Jun Itami

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Background/Aim: The purpose of the present study was to compare intensity-modulated radiation therapy (IMRT) plan with (Bone Marrow Sparing (BMS) - IMRT) or without (normal-IMRT) an intention of avoiding bone marrow in order to minimize treatment-related toxicity. Patients and Methods: Computed tomography (CT) images of 10 consecutive postoperative cervical cancer patients were used. All patients were already treated by normal-IMRT. BMS-IMRTs were created for this study and dose-volume histogram parameters were compared. Results: Both planning target volume (PTV) D95% and D97% were statistically lower in BMS-IMRT than normal-IMRT, however, the difference was lower than 3%. There were no statistical differences between BMS-IMRT and normal-IMRT in the mean value of rectum V_30Gy, V_50Gy; bladder V_45Gy, V_50Gy; Bowel V_35Gy, and V_50Gy. Both in whole pelvic bone (WPB) and inner cavity of pelvic bone (ICPB), the mean value of V_10Gy, V_30Gy, and V_40Gy of BMS-IMRT were statistically lower than that of normal-IMRT. Conclusion: Both lower and higher dose for WPB as well as ICPB were effectively lowered by BMS-IMRT.

Original language	English
Pages (from-to)	5091-5098
Number of pages	8
Journal	Anticancer research
Volume	34
Issue number	9
Publication status	Published - Sept 1 2014
Externally published	Yes

Keywords

Bone marrow sparing
Cervical cancer
IMRT
Postoperative radiation therapy
Radical hysterectomy

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "A dosimetric analysis of intensity-modulated radiation therapy with bone marrow sparing for cervical cancer",

abstract = "Background/Aim: The purpose of the present study was to compare intensity-modulated radiation therapy (IMRT) plan with (Bone Marrow Sparing (BMS) - IMRT) or without (normal-IMRT) an intention of avoiding bone marrow in order to minimize treatment-related toxicity. Patients and Methods: Computed tomography (CT) images of 10 consecutive postoperative cervical cancer patients were used. All patients were already treated by normal-IMRT. BMS-IMRTs were created for this study and dose-volume histogram parameters were compared. Results: Both planning target volume (PTV) D95% and D97% were statistically lower in BMS-IMRT than normal-IMRT, however, the difference was lower than 3%. There were no statistical differences between BMS-IMRT and normal-IMRT in the mean value of rectum V30Gy, V50Gy; bladder V45Gy, V50Gy; Bowel V35Gy, and V50Gy. Both in whole pelvic bone (WPB) and inner cavity of pelvic bone (ICPB), the mean value of V10Gy, V30Gy, and V40Gy of BMS-IMRT were statistically lower than that of normal-IMRT. Conclusion: Both lower and higher dose for WPB as well as ICPB were effectively lowered by BMS-IMRT.",

keywords = "Bone marrow sparing, Cervical cancer, IMRT, Postoperative radiation therapy, Radical hysterectomy",

author = "Naoya Murakami and Hiroyuki Okamoto and Takahiro Kasamatsu and Kazuma Kobayashi and Ken Harada and Mayuka Kitaguchi and Shuhei Sekii and Kana Takahashi and Kotaro Yoshio and Koji Inaba and Madoka Morota and Minako Sumi and Takafumi Toita and Yoshinori Ito and Jun Itami",

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language = "English",

volume = "34",

pages = "5091--5098",

journal = "Anticancer Research",

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T1 - A dosimetric analysis of intensity-modulated radiation therapy with bone marrow sparing for cervical cancer

AU - Murakami, Naoya

AU - Okamoto, Hiroyuki

AU - Kasamatsu, Takahiro

AU - Kobayashi, Kazuma

AU - Harada, Ken

AU - Kitaguchi, Mayuka

AU - Sekii, Shuhei

AU - Takahashi, Kana

AU - Yoshio, Kotaro

AU - Inaba, Koji

AU - Morota, Madoka

AU - Sumi, Minako

AU - Toita, Takafumi

AU - Ito, Yoshinori

AU - Itami, Jun

PY - 2014/9/1

Y1 - 2014/9/1

N2 - Background/Aim: The purpose of the present study was to compare intensity-modulated radiation therapy (IMRT) plan with (Bone Marrow Sparing (BMS) - IMRT) or without (normal-IMRT) an intention of avoiding bone marrow in order to minimize treatment-related toxicity. Patients and Methods: Computed tomography (CT) images of 10 consecutive postoperative cervical cancer patients were used. All patients were already treated by normal-IMRT. BMS-IMRTs were created for this study and dose-volume histogram parameters were compared. Results: Both planning target volume (PTV) D95% and D97% were statistically lower in BMS-IMRT than normal-IMRT, however, the difference was lower than 3%. There were no statistical differences between BMS-IMRT and normal-IMRT in the mean value of rectum V30Gy, V50Gy; bladder V45Gy, V50Gy; Bowel V35Gy, and V50Gy. Both in whole pelvic bone (WPB) and inner cavity of pelvic bone (ICPB), the mean value of V10Gy, V30Gy, and V40Gy of BMS-IMRT were statistically lower than that of normal-IMRT. Conclusion: Both lower and higher dose for WPB as well as ICPB were effectively lowered by BMS-IMRT.

AB - Background/Aim: The purpose of the present study was to compare intensity-modulated radiation therapy (IMRT) plan with (Bone Marrow Sparing (BMS) - IMRT) or without (normal-IMRT) an intention of avoiding bone marrow in order to minimize treatment-related toxicity. Patients and Methods: Computed tomography (CT) images of 10 consecutive postoperative cervical cancer patients were used. All patients were already treated by normal-IMRT. BMS-IMRTs were created for this study and dose-volume histogram parameters were compared. Results: Both planning target volume (PTV) D95% and D97% were statistically lower in BMS-IMRT than normal-IMRT, however, the difference was lower than 3%. There were no statistical differences between BMS-IMRT and normal-IMRT in the mean value of rectum V30Gy, V50Gy; bladder V45Gy, V50Gy; Bowel V35Gy, and V50Gy. Both in whole pelvic bone (WPB) and inner cavity of pelvic bone (ICPB), the mean value of V10Gy, V30Gy, and V40Gy of BMS-IMRT were statistically lower than that of normal-IMRT. Conclusion: Both lower and higher dose for WPB as well as ICPB were effectively lowered by BMS-IMRT.

KW - Bone marrow sparing

KW - Cervical cancer

KW - IMRT

KW - Postoperative radiation therapy

KW - Radical hysterectomy

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IS - 9

ER -

A dosimetric analysis of intensity-modulated radiation therapy with bone marrow sparing for cervical cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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