A fermented grain food product extract ameliorates tumor promoter-induced skin oxidative stress

Yoshimasa Nakamura; Toshihiko Osawa

doi:10.3136/fstr.11.373

A fermented grain food product extract ameliorates tumor promoter-induced skin oxidative stress

Research output: Contribution to journal › Article › peer-review

Abstract

We demonstrated that a dietary supplement, Antioxidant Biofactor (AOB®), a fermented grain food, inhibits phorbol ester (TPA)-induced inflammatory responses. Pretreatment of mouse skin with ethyl acetate extract of AOB (0.5 mg) significantly attenuated the hydrogen peroxide level in mouse skin without inhibition of edema formation. Also, exposure of AOB extract to differentiated HL-60 cells resulted in dose-dependent inhibition of TPA-induced Superoxide generation, which was stronger than those of the raw materials of AOB. Our results suggest that AOB is effective for prevention of skin oxidative stress.

Original language	English
Pages (from-to)	373-375
Number of pages	3
Journal	Food Science and Technology Research
Volume	11
Issue number	4
DOIs	https://doi.org/10.3136/fstr.11.373
Publication status	Published - Dec 2005

Keywords

Antioxidant
Mouse skin
Oxidative stress
Phorbol ester

ASJC Scopus subject areas

Biotechnology
Food Science
Chemical Engineering(all)
Industrial and Manufacturing Engineering
Marketing

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10.3136/fstr.11.373

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title = "A fermented grain food product extract ameliorates tumor promoter-induced skin oxidative stress",

abstract = "We demonstrated that a dietary supplement, Antioxidant Biofactor (AOB{\textregistered}), a fermented grain food, inhibits phorbol ester (TPA)-induced inflammatory responses. Pretreatment of mouse skin with ethyl acetate extract of AOB (0.5 mg) significantly attenuated the hydrogen peroxide level in mouse skin without inhibition of edema formation. Also, exposure of AOB extract to differentiated HL-60 cells resulted in dose-dependent inhibition of TPA-induced Superoxide generation, which was stronger than those of the raw materials of AOB. Our results suggest that AOB is effective for prevention of skin oxidative stress.",

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author = "Yoshimasa Nakamura and Toshihiko Osawa",

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AB - We demonstrated that a dietary supplement, Antioxidant Biofactor (AOB®), a fermented grain food, inhibits phorbol ester (TPA)-induced inflammatory responses. Pretreatment of mouse skin with ethyl acetate extract of AOB (0.5 mg) significantly attenuated the hydrogen peroxide level in mouse skin without inhibition of edema formation. Also, exposure of AOB extract to differentiated HL-60 cells resulted in dose-dependent inhibition of TPA-induced Superoxide generation, which was stronger than those of the raw materials of AOB. Our results suggest that AOB is effective for prevention of skin oxidative stress.

KW - Antioxidant

KW - Mouse skin

KW - Oxidative stress

KW - Phorbol ester

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A fermented grain food product extract ameliorates tumor promoter-induced skin oxidative stress

Abstract

Keywords

ASJC Scopus subject areas

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