A genetic linkage map of rat chromosome 9 with a new locus for variant activity of liver aldehyde oxidase

Tetsuo Kunieda; Eiji Kobayashi; Motokazu Tachibana; Hiroshi Ikadai

doi:10.1538/expanim.48.43

A genetic linkage map of rat chromosome 9 with a new locus for variant activity of liver aldehyde oxidase

Tetsuo Kunieda, Eiji Kobayashi, Motokazu Tachibana, Hiroshi Ikadai

Graduate School of Environmental and Life Science

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A genetic linkage map of rat chromosome 9 consisting of five loci including a new biochemical marker representing a genetic variation of the activity of the liver aldehyde oxidase, (Aox) was constructed. Linkage analysis of the five loci among 92 backcross progeny of (WKS/lar x IS/lar)F₁ x WKS/lar revealed significant linkages between these loci. Minimizing crossover frequency resulted in the best gene order: Aox-D9Mit4-Gls-Cryg-Tp53l1. The homologues of the Cryg, Gls, and Aox genes have been mapped on mouse chromosome 1 and human chromosome 2q. The present findings provide further evidence for the conservation of synteny among these regions of rat, mouse, and human chromosomes.

Original language	English
Pages (from-to)	43-45
Number of pages	3
Journal	Experimental Animals
Volume	48
Issue number	1
DOIs	https://doi.org/10.1538/expanim.48.43
Publication status	Published - Jan 1999

Keywords

Aox
Linkage map
Rat

ASJC Scopus subject areas

Animal Science and Zoology
Biochemistry, Genetics and Molecular Biology(all)
veterinary(all)

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abstract = "A genetic linkage map of rat chromosome 9 consisting of five loci including a new biochemical marker representing a genetic variation of the activity of the liver aldehyde oxidase, (Aox) was constructed. Linkage analysis of the five loci among 92 backcross progeny of (WKS/lar x IS/lar)F1 x WKS/lar revealed significant linkages between these loci. Minimizing crossover frequency resulted in the best gene order: Aox-D9Mit4-Gls-Cryg-Tp53l1. The homologues of the Cryg, Gls, and Aox genes have been mapped on mouse chromosome 1 and human chromosome 2q. The present findings provide further evidence for the conservation of synteny among these regions of rat, mouse, and human chromosomes.",

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AU - Kobayashi, Eiji

AU - Tachibana, Motokazu

AU - Ikadai, Hiroshi

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AB - A genetic linkage map of rat chromosome 9 consisting of five loci including a new biochemical marker representing a genetic variation of the activity of the liver aldehyde oxidase, (Aox) was constructed. Linkage analysis of the five loci among 92 backcross progeny of (WKS/lar x IS/lar)F1 x WKS/lar revealed significant linkages between these loci. Minimizing crossover frequency resulted in the best gene order: Aox-D9Mit4-Gls-Cryg-Tp53l1. The homologues of the Cryg, Gls, and Aox genes have been mapped on mouse chromosome 1 and human chromosome 2q. The present findings provide further evidence for the conservation of synteny among these regions of rat, mouse, and human chromosomes.

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A genetic linkage map of rat chromosome 9 with a new locus for variant activity of liver aldehyde oxidase

Abstract

Keywords

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