A Japanese Patient with Gastric Cancer and Dihydropyrimidine Dehydrogenase Deficiency Presenting with DPYD Variants

Mikako Ishiguro; Ryuta Takenaka; Kenichiro Ogura; Akira Hiratsuka; Hiromasa Takeda; Daisuke Kawai; Hirofumi Tsugeno; Shigeatsu Fujiki; Hiroyuki Okada

A Japanese Patient with Gastric Cancer and Dihydropyrimidine Dehydrogenase Deficiency Presenting with DPYD Variants

Mikako Ishiguro, Ryuta Takenaka, Kenichiro Ogura, Akira Hiratsuka, Hiromasa Takeda, Daisuke Kawai, Hirofumi Tsugeno, Shigeatsu Fujiki, Hiroyuki Okada

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

A 63-year-old Japanese male with stomach adenocarcinoma received oral 5-fluorouracil derivative, cisplatin and trastuzumab chemotherapy. On day 8, severe diarrhea and mucositis developed; chemotherapy was stopped. On day 14, the patient developed renal dysfunction and febrile neutropenia. He also suffered from pneumonia due to Candida albicans. Systemic symptoms improved after intensive conservative treatment. Best supportive care was continued until the patient died from gastric cancer. The dihydropyrimidine dehydrogenase protein level was low at 3.18 U/mg protein. The result of DPYD genotyping revealed three variants at positions 1615 (G>A), 1627 (A>G), and 1896 (T>C) in exons 13, 13, and 14, respectively.

Original language	English
Pages (from-to)	557-562
Number of pages	6
Journal	Acta medica Okayama
Volume	74
Issue number	6
Publication status	Published - 2020

Keywords

5-fluorouracil
DPYD variant
dihydropyrimidine dehydrogenase deficiency
gastric cancer

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "A Japanese Patient with Gastric Cancer and Dihydropyrimidine Dehydrogenase Deficiency Presenting with DPYD Variants",

abstract = "A 63-year-old Japanese male with stomach adenocarcinoma received oral 5-fluorouracil derivative, cisplatin and trastuzumab chemotherapy. On day 8, severe diarrhea and mucositis developed; chemotherapy was stopped. On day 14, the patient developed renal dysfunction and febrile neutropenia. He also suffered from pneumonia due to Candida albicans. Systemic symptoms improved after intensive conservative treatment. Best supportive care was continued until the patient died from gastric cancer. The dihydropyrimidine dehydrogenase protein level was low at 3.18 U/mg protein. The result of DPYD genotyping revealed three variants at positions 1615 (G>A), 1627 (A>G), and 1896 (T>C) in exons 13, 13, and 14, respectively.",

keywords = "5-fluorouracil, DPYD variant, dihydropyrimidine dehydrogenase deficiency, gastric cancer",

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journal = "Acta medica Okayama",

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T1 - A Japanese Patient with Gastric Cancer and Dihydropyrimidine Dehydrogenase Deficiency Presenting with DPYD Variants

AU - Ishiguro, Mikako

AU - Takenaka, Ryuta

AU - Ogura, Kenichiro

AU - Hiratsuka, Akira

AU - Takeda, Hiromasa

AU - Kawai, Daisuke

AU - Tsugeno, Hirofumi

AU - Fujiki, Shigeatsu

AU - Okada, Hiroyuki

PY - 2020

Y1 - 2020

N2 - A 63-year-old Japanese male with stomach adenocarcinoma received oral 5-fluorouracil derivative, cisplatin and trastuzumab chemotherapy. On day 8, severe diarrhea and mucositis developed; chemotherapy was stopped. On day 14, the patient developed renal dysfunction and febrile neutropenia. He also suffered from pneumonia due to Candida albicans. Systemic symptoms improved after intensive conservative treatment. Best supportive care was continued until the patient died from gastric cancer. The dihydropyrimidine dehydrogenase protein level was low at 3.18 U/mg protein. The result of DPYD genotyping revealed three variants at positions 1615 (G>A), 1627 (A>G), and 1896 (T>C) in exons 13, 13, and 14, respectively.

AB - A 63-year-old Japanese male with stomach adenocarcinoma received oral 5-fluorouracil derivative, cisplatin and trastuzumab chemotherapy. On day 8, severe diarrhea and mucositis developed; chemotherapy was stopped. On day 14, the patient developed renal dysfunction and febrile neutropenia. He also suffered from pneumonia due to Candida albicans. Systemic symptoms improved after intensive conservative treatment. Best supportive care was continued until the patient died from gastric cancer. The dihydropyrimidine dehydrogenase protein level was low at 3.18 U/mg protein. The result of DPYD genotyping revealed three variants at positions 1615 (G>A), 1627 (A>G), and 1896 (T>C) in exons 13, 13, and 14, respectively.

KW - 5-fluorouracil

KW - DPYD variant

KW - dihydropyrimidine dehydrogenase deficiency

KW - gastric cancer

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M3 - Article

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AN - SCOPUS:85098700418

SN - 0386-300X

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EP - 562

JO - Acta medica Okayama

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ER -

A Japanese Patient with Gastric Cancer and Dihydropyrimidine Dehydrogenase Deficiency Presenting with DPYD Variants

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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