TY - JOUR
T1 - A micro-PET/CT approach using O-(2-[18F]fluoroethyl)-l-tyrosine in an experimental animal model of F98 glioma for BNCT
AU - Menichetti, L.
AU - Petroni, D.
AU - Panetta, D.
AU - Burchielli, S.
AU - Bortolussi, Silva
AU - Matteucci, M.
AU - Pascali, G.
AU - Del Turco, S.
AU - Del Guerra, A.
AU - Altieri, S.
AU - Salvadori, P. A.
PY - 2011/12
Y1 - 2011/12
N2 - The present study focuses on a micro-PET/CT application to be used for experimental Boron Neutron Capture Therapy (BNCT), which integrates, in the same frame, micro-CT derived anatomy and PET radiotracer distribution. Preliminary results have demonstrated that 18F-fluoroethyl-tyrosine (FET)/PET allows the identification of the extent of cerebral lesions in F98 tumor bearing rat. Neutron autoradiography and α-spectrometry on axial tissues slices confirmed the tumor localization and extraction, after the administration of fructose-boronophenylalanine (BPA). Therefore, FET-PET approach can be used to assess the transport, the net influx, and the accumulation of FET, as an aromatic amino acid analog of BPA, in experimental animal model. Coregistered micro-CT images allowed the accurate morphological localization of the radiotracer distribution and its potential use for experimental BNCT.
AB - The present study focuses on a micro-PET/CT application to be used for experimental Boron Neutron Capture Therapy (BNCT), which integrates, in the same frame, micro-CT derived anatomy and PET radiotracer distribution. Preliminary results have demonstrated that 18F-fluoroethyl-tyrosine (FET)/PET allows the identification of the extent of cerebral lesions in F98 tumor bearing rat. Neutron autoradiography and α-spectrometry on axial tissues slices confirmed the tumor localization and extraction, after the administration of fructose-boronophenylalanine (BPA). Therefore, FET-PET approach can be used to assess the transport, the net influx, and the accumulation of FET, as an aromatic amino acid analog of BPA, in experimental animal model. Coregistered micro-CT images allowed the accurate morphological localization of the radiotracer distribution and its potential use for experimental BNCT.
KW - [18F]F-BPA
KW - [18F]FET
KW - BNCT
KW - Head and neck cancer
KW - Positron emission tomography
KW - Treatment planning
UR - http://www.scopus.com/inward/record.url?scp=80055108249&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80055108249&partnerID=8YFLogxK
U2 - 10.1016/j.apradiso.2011.02.037
DO - 10.1016/j.apradiso.2011.02.037
M3 - Article
C2 - 21458282
AN - SCOPUS:80055108249
SN - 0969-8043
VL - 69
SP - 1717
EP - 1720
JO - Applied Radiation and Isotopes
JF - Applied Radiation and Isotopes
IS - 12
ER -
