A mysterious triangle of blood, bones, and nerves

Noboru Asada, Yoshio Katayama

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


The relationship between bone tissue and bone marrow, which is responsible for hematopoiesis, is inseparable. Osteoblasts and osteocytes, which produce and consist of bone tissue, regulate the function of hematopoietic stem cells (HSC), the ancestors of all hematopoietic cells in the bone marrow. The peripheral nervous system finely regulates bone remodeling in bone tissue and modulates HSC function within the bone marrow, either directly or indirectly via modification of the HSC niche function. Peripheral nerve signals also play an important role in the development and progression of malignant tumors (including hematopoietic tumors) and normal tissues, and peripheral nerve control is emerging as a potential new therapeutic target. In this review, we summarize recent findings on the linkage among blood system, bone tissue, and peripheral nerves.

Original languageEnglish
Pages (from-to)404-414
Number of pages11
JournalJournal of Bone and Mineral Metabolism
Issue number3
Publication statusPublished - May 2023


  • Bone remodeling
  • Hematopoiesis
  • Nervous system
  • Niche

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology


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