A nationwide analysis of renal and patient outcomes for adults with lupus nephritis in Japan

Hidekazu Ikeuchi, Hitoshi Sugiyama, Hiroshi Sato, Hitoshi Yokoyama, Shoichi Maruyama, Masashi Mukoyama, Hiroki Hayashi, Tatsuo Tsukamoto, Michio Fukuda, Kunihiro Yamagata, Eiji Ishikawa, Keiko Uchida, Yuji Kamijo, Naoki Nakagawa, Kazuhiko Tsuruya, Yoshihisa Nojima, Keiju Hiromura

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Background: The prognosis of lupus nephritis (LN) has improved following the introduction of effective immunosuppressive therapy and progress in supportive care. This study examined recent renal and patient prognosis for adults with LN in Japan. Methods: We conducted a nationwide retrospective cohort study of LN patients who received a renal biopsy between 2007 and 2012 that were registered in the Japan Renal Biopsy Registry. Of 623 registered adults with LN from 25 institutions and their affiliated or community hospitals, 489 were eligible for this study. Results: The median age at renal biopsy was 39 years, and 82.2% of patients were female. Renal biopsies were performed in 348 patients with new-onset LN, 106 with relapse LN, and 35 with refractory LN. The distribution of ISN/RPS 2003 Classes was as follows: I 1.6%; II 5.3%; III (± V) 27.0%; IV (± V) 47.0%; V 18.4%; VI 0.6%. During the median observation period of 63.8 months, 36 patients (7.3%) reached a doubling of serum creatinine or end-stage kidney disease (ESKD), and 28 patients (5.7%) died. The 5 year renal and patient survival rates were 93.9% and 94.7%, respectively. Multivariate analysis revealed body mass index (BMI) and estimated glomerular filtration rate (eGFR) were independent risk factors for a doubling of serum creatinine in ESKD. Age and eGFR were independent risk factors for death. Conclusion: Recent prognosis for adults with LN are relatively good in Japan. Risk factors for impaired renal function are BMI and eGFR at renal biopsy, while age and eGFR are risk factors for death.

Original languageEnglish
Pages (from-to)898-908
Number of pages11
JournalClinical and Experimental Nephrology
Issue number9
Publication statusPublished - Sept 2022
Externally publishedYes


  • End-stage kidney disease
  • Patient prognosis
  • Renal prognosis
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)


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