A new class of diacidic nonpeptide angiotensin II receptor antagonists

N. Cho, K. Kubo, S. Furuya, Y. Sugiura, Yasuma T., Kohara Y., Ojima M., Inada Y., Nishikawa K., Naka T.

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


A novel series of heterocyclic compounds I bearing two acidic funcitonalities, a carboxyl group and a tetrazole ring, was prepared and evaluated for in vitro and in vivo angiotensin II (AII) antagonistic activity. These compounds showed significantly more potent All antagonistic activities than the parent compounds without the carboxyl groups. This structure-activity relationhsip (SAR) study revealed the importance of the carboxyl group attached to the heterocyclic moieties especially for insurmountable antagonism and enhancement of in vivo (po) activity.

Original languageEnglish
Pages (from-to)35-40
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Issue number1
Publication statusPublished - Jan 6 1994
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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