A new modified classification of bronchial asthma based on clinical symptoms

Yoshiro Tanizaki; Hikaru Kitani; Morihiro Okazaki; Takashi Mifune; Fumihiro Mitsunobu; Tomoharu Okano; Naoko Honke; Ikuro Kimura

doi:10.2169/internalmedicine.32.197

A new modified classification of bronchial asthma based on clinical symptoms

Yoshiro Tanizaki, Hikaru Kitani, Morihiro Okazaki, Takashi Mifune, Fumihiro Mitsunobu, Tomoharu Okano, Naoko Honke, Ikuro Kimura

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The clinical features of four asthma types, Ia-1 (bronchospasm with 0-49ml/day of expectoration), Ia-2 (with 50-99ml/day), Ib (over 100ml/day), and II (bronchiolar obstruction), as classified by the clinical symptoms, were compared in 119 patients with bronchial asthma. The age of onset characteristic symptoms of each asthma type was in the 20's in types Ia-1 and Ia-2, in the 30's in type Ib, and in the 40's in type II patients. A significant increase in the number of neutrophils in bronchoalveolar lavage (BAL) fluid was found in type II patients. The proportion of BAL eosinophils was significantly higher in types Ia-2 and Ib asthma patients compared with that in type Ia-1 patients. The BAL eosinophil count was significantly higher in type Ib than in type Ia-2 patients. The FEV1.0% and %V₂₅ values were significantly lower in patients with type II asthma than in the patients with the other asthma types. Steroid-dependent intractable asthma (SDIA) was more often observed in patients with type Ib or type II asthma. (Internal Medicine 32: 197-203, 1993).

Original language	English
Pages (from-to)	197-203
Number of pages	7
Journal	Internal Medicine
Volume	32
Issue number	3
DOIs	https://doi.org/10.2169/internalmedicine.32.197
Publication status	Published - 1993
Externally published	Yes

Keywords

BAL cells
age at onset
glucocorticoids
patient age
pulmonary function

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.32.197

Cite this

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title = "A new modified classification of bronchial asthma based on clinical symptoms",

abstract = "The clinical features of four asthma types, Ia-1 (bronchospasm with 0-49ml/day of expectoration), Ia-2 (with 50-99ml/day), Ib (over 100ml/day), and II (bronchiolar obstruction), as classified by the clinical symptoms, were compared in 119 patients with bronchial asthma. The age of onset characteristic symptoms of each asthma type was in the 20's in types Ia-1 and Ia-2, in the 30's in type Ib, and in the 40's in type II patients. A significant increase in the number of neutrophils in bronchoalveolar lavage (BAL) fluid was found in type II patients. The proportion of BAL eosinophils was significantly higher in types Ia-2 and Ib asthma patients compared with that in type Ia-1 patients. The BAL eosinophil count was significantly higher in type Ib than in type Ia-2 patients. The FEV1.0% and %V25 values were significantly lower in patients with type II asthma than in the patients with the other asthma types. Steroid-dependent intractable asthma (SDIA) was more often observed in patients with type Ib or type II asthma. (Internal Medicine 32: 197-203, 1993).",

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AU - Tanizaki, Yoshiro

AU - Kitani, Hikaru

AU - Okazaki, Morihiro

AU - Mifune, Takashi

AU - Mitsunobu, Fumihiro

AU - Okano, Tomoharu

AU - Honke, Naoko

AU - Kimura, Ikuro

PY - 1993

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N2 - The clinical features of four asthma types, Ia-1 (bronchospasm with 0-49ml/day of expectoration), Ia-2 (with 50-99ml/day), Ib (over 100ml/day), and II (bronchiolar obstruction), as classified by the clinical symptoms, were compared in 119 patients with bronchial asthma. The age of onset characteristic symptoms of each asthma type was in the 20's in types Ia-1 and Ia-2, in the 30's in type Ib, and in the 40's in type II patients. A significant increase in the number of neutrophils in bronchoalveolar lavage (BAL) fluid was found in type II patients. The proportion of BAL eosinophils was significantly higher in types Ia-2 and Ib asthma patients compared with that in type Ia-1 patients. The BAL eosinophil count was significantly higher in type Ib than in type Ia-2 patients. The FEV1.0% and %V25 values were significantly lower in patients with type II asthma than in the patients with the other asthma types. Steroid-dependent intractable asthma (SDIA) was more often observed in patients with type Ib or type II asthma. (Internal Medicine 32: 197-203, 1993).

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KW - glucocorticoids

KW - patient age

KW - pulmonary function

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A new modified classification of bronchial asthma based on clinical symptoms

Abstract

Keywords

ASJC Scopus subject areas

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