A new paradigm for the action of reactive oxygen species in the photoinhibition of photosystem II

Yoshitaka Nishiyama, Suleyman I. Allakhverdiev, Norio Murata

    Research output: Contribution to journalReview articlepeer-review

    588 Citations (Scopus)


    Inhibition of the activity of photosystem II (PSII) under strong light is referred to as photoinhibition. This phenomenon is due to the imbalance between the rate of photodamage to PSII and the rate of the repair of damaged PSII. Photodamage is initiated by the direct effects of light on the oxygen-evolving complex and, thus, photodamage to PSII is unavoidable. Studies of the effects of oxidative stress on photodamage and subsequent repair have revealed that reactive oxygen species (ROS) act primarily by inhibiting the repair of photodamaged PSII and not by damaging PSII directly. Thus, strong light has two distinct effects on PSII; it damages PSII directly and it inhibits the repair of PSII via production of ROS. Investigations of the ROS-induced inhibition of repair have demonstrated that ROS suppress the synthesis de novo of proteins and, in particular, of the D1 protein, that are required for the repair of PSII. Moreover, a primary target for inhibition by ROS appears to be the elongation step of translation. Inhibition of the repair of PSII by ROS is accelerated by the deceleration of the Calvin cycle that occurs when the availability of CO2 is limited. In this review, we present a new paradigm for the action of ROS in photoinhibition.

    Original languageEnglish
    Pages (from-to)742-749
    Number of pages8
    JournalBiochimica et Biophysica Acta - Bioenergetics
    Issue number7
    Publication statusPublished - Jul 2006


    • Photoinhibition
    • Photosystem II
    • Protein synthesis
    • Reactive oxygen species
    • Repair

    ASJC Scopus subject areas

    • Biophysics
    • Biochemistry
    • Cell Biology


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