TY - JOUR
T1 - A new pseudo-alkaloid taxane and a new rearranged taxane from the needles of Taxus canadensis
AU - Zhang, Manli
AU - Huo, Changhong
AU - Dong, Mei
AU - Li, Ligeng
AU - Sauriol, Françoise
AU - Shi, Qingwen
AU - Gu, Yucheng
AU - Kiyota, Hiromasa
AU - Cong, Bin
N1 - Funding Information:
The work reported in this paper was financially supported by the Foundation for Researching New Drugs of People’s Republic of China (No: 2003AA2Z3527), the Scientific Research Foundation for the Returned Overseas Chinese Scholars from Hebei Province, and the Scientific Research Foundation of Hebei Province (08B032) (QWS). We wish to extend our sincere thanks for financial support from Syngenta Ltd. (2005-Hebei Medical University-Syngenta-01).
PY - 2008/8
Y1 - 2008/8
N2 - A new taxane with an amino side chain on C-5 and a new 11(15→1) abeotaxane having a tetrahydrofuran ring along carbon atoms C-2, C-3, C-4, C-20 identified for the first time from the needles of the Canadian yew, Taxus canadensis. Their structures were characterized as 2α,7β,9α, 10β,13-pentaacetoxy-11β-hydroxy-5α-(2′-hydroxy,3′-N, N-dimethylamino-3′-phenyl)-propionyloxytaxa-4(20),12-diene (1) and 13α,20β-diacetoxy-5α,7β,9α,10β- tetrahydroxy2α,20-epoxy-11(15→1)abeotaxa-11,15-diene (2) on the basis of ID, 2D NMR spectroscopy and high-resolution FABMS analysis. Taxane 1 contains a rare C-12, C-13 double bond and a basic side chain, while taxane 2 bears a rare isopropenyl group at C-1.
AB - A new taxane with an amino side chain on C-5 and a new 11(15→1) abeotaxane having a tetrahydrofuran ring along carbon atoms C-2, C-3, C-4, C-20 identified for the first time from the needles of the Canadian yew, Taxus canadensis. Their structures were characterized as 2α,7β,9α, 10β,13-pentaacetoxy-11β-hydroxy-5α-(2′-hydroxy,3′-N, N-dimethylamino-3′-phenyl)-propionyloxytaxa-4(20),12-diene (1) and 13α,20β-diacetoxy-5α,7β,9α,10β- tetrahydroxy2α,20-epoxy-11(15→1)abeotaxa-11,15-diene (2) on the basis of ID, 2D NMR spectroscopy and high-resolution FABMS analysis. Taxane 1 contains a rare C-12, C-13 double bond and a basic side chain, while taxane 2 bears a rare isopropenyl group at C-1.
KW - Taxaceae
KW - Taxane
KW - Taxus canadensis
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U2 - 10.1515/znb-2008-0814
DO - 10.1515/znb-2008-0814
M3 - Article
AN - SCOPUS:49749083084
SN - 0932-0776
VL - 63
SP - 1005
EP - 1011
JO - Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences
JF - Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences
IS - 8
ER -