A novel 3,8-seco-taxane metabolite from the seeds of the Chinese yew, Taxus mairei

Qing Wen Shi; Li Geng Li; Zuo Ping Li; Cong Mei Cao; Hiromasa Kiyota

doi:10.1016/j.tetlet.2005.07.040

A novel 3,8-seco-taxane metabolite from the seeds of the Chinese yew, Taxus mairei

Qing Wen Shi, Li Geng Li, Zuo Ping Li, Cong Mei Cao, Hiromasa Kiyota

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

The structure of a novel 3,8-seco-bicyclic taxanoid metabolite, isolated from the methanol extract of seeds of the Chinese yew, Taxus mairei, was established as (11αH)-3,8-seco-taxa-3E,7E,12(18)-triene-2α,6α, 9β-triol (1) on the basis of spectral analysis including ¹H NMR, ¹³C NMR, HMQC, HMBC, NOESY and HR-FABMS.

Original language	English
Pages (from-to)	6301-6303
Number of pages	3
Journal	Tetrahedron Letters
Volume	46
Issue number	37
DOIs	https://doi.org/10.1016/j.tetlet.2005.07.040
Publication status	Published - Sept 12 2005
Externally published	Yes

Keywords

Bicyclic taxanes
Isolation
Taxanes
Taxus mairei

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2005.07.040

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@article{f1c79a2c463b454e9f7cfcfb104f5910,

title = "A novel 3,8-seco-taxane metabolite from the seeds of the Chinese yew, Taxus mairei",

abstract = "The structure of a novel 3,8-seco-bicyclic taxanoid metabolite, isolated from the methanol extract of seeds of the Chinese yew, Taxus mairei, was established as (11αH)-3,8-seco-taxa-3E,7E,12(18)-triene-2α,6α, 9β-triol (1) on the basis of spectral analysis including 1H NMR, 13C NMR, HMQC, HMBC, NOESY and HR-FABMS.",

keywords = "Bicyclic taxanes, Isolation, Taxanes, Taxus mairei",

author = "Shi, {Qing Wen} and Li, {Li Geng} and Li, {Zuo Ping} and Cao, {Cong Mei} and Hiromasa Kiyota",

note = "Funding Information: This work was supported partly by the Foundation for Researching New Drugs of People{\textquoteright}s Republic of China (No: 2003AA2Z3527) and Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry of PR China. We thank Dr. Takayuki Oritani, emeritus professor of Tohoku University of Japan, for providing extracts for this work. ",

year = "2005",

month = sep,

day = "12",

doi = "10.1016/j.tetlet.2005.07.040",

language = "English",

volume = "46",

pages = "6301--6303",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "37",

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T1 - A novel 3,8-seco-taxane metabolite from the seeds of the Chinese yew, Taxus mairei

AU - Shi, Qing Wen

AU - Li, Li Geng

AU - Li, Zuo Ping

AU - Cao, Cong Mei

AU - Kiyota, Hiromasa

N1 - Funding Information: This work was supported partly by the Foundation for Researching New Drugs of People’s Republic of China (No: 2003AA2Z3527) and Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry of PR China. We thank Dr. Takayuki Oritani, emeritus professor of Tohoku University of Japan, for providing extracts for this work.

PY - 2005/9/12

Y1 - 2005/9/12

N2 - The structure of a novel 3,8-seco-bicyclic taxanoid metabolite, isolated from the methanol extract of seeds of the Chinese yew, Taxus mairei, was established as (11αH)-3,8-seco-taxa-3E,7E,12(18)-triene-2α,6α, 9β-triol (1) on the basis of spectral analysis including 1H NMR, 13C NMR, HMQC, HMBC, NOESY and HR-FABMS.

AB - The structure of a novel 3,8-seco-bicyclic taxanoid metabolite, isolated from the methanol extract of seeds of the Chinese yew, Taxus mairei, was established as (11αH)-3,8-seco-taxa-3E,7E,12(18)-triene-2α,6α, 9β-triol (1) on the basis of spectral analysis including 1H NMR, 13C NMR, HMQC, HMBC, NOESY and HR-FABMS.

KW - Bicyclic taxanes

KW - Isolation

KW - Taxanes

KW - Taxus mairei

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DO - 10.1016/j.tetlet.2005.07.040

M3 - Article

AN - SCOPUS:23744487031

SN - 0040-4039

VL - 46

SP - 6301

EP - 6303

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 37

ER -

A novel 3,8-seco-taxane metabolite from the seeds of the Chinese yew, Taxus mairei

Abstract

Keywords

ASJC Scopus subject areas

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