A novel clinical entity, IgG4-relateddisease (IgG4RD): General concept and details

Hisanori Umehara; Kazuichi Okazaki; Yasufumi Masaki; Mitsuhiro Kawano; Motohisa Yamamoto; Takako Saeki; Shoko Matsui; Takayuki Sumida; Tsuneyo Mimori; Yoshiya Tanaka; Kazuo Tsubota; Tadashi Yoshino; Shigeyuki Kawa; Ritsuro Suzuki; Tsutomu Takegami; Naohisa Tomosugi; Nozomu Kurose; Yasuhito Ishigaki; Atsushi Azumi; Masaru Kojima; Shigeo Nakamura; Dai Inoue; Keita Fujikawa; Hideaki Hamano; Keiji Kubo; Hiroshi Yamamoto; Mitsuyosi Hirokawa; Kunihiko Itoh; Terumi Kamisawa; Daisuke Kawabata; Morio Matsumoto; Seijiro Minamoto; Kayoko Murayama; Susumu Nishiyama; Yoko Ogawa; Tomoki Origuchi; Norihide Oyama; Yasuharu Sato; Masao Seto; Susumu Sugai; Norifumi Tsukamoto; Masayuki Takahira; Hiroki Takahashi; Hiroto Tsuboi; Yuko Waseda; Kazuko Kitagawa; Takayuki Nojima; Hitoshi Yokoyama; Hisao Tonami; Toshihiro Fukushima; Masao Tanaka; Yoshimasa Fujita; Toshioki Sawaki; Takafumi Kawanami; Miyuki Miki; Haruka Iwao; Akio Nakajima; Takuji Nakamura

doi:10.1007/s10165-011-0508-6

A novel clinical entity, IgG4-relateddisease (IgG4RD): General concept and details

Hisanori Umehara, Kazuichi Okazaki, Yasufumi Masaki, Mitsuhiro Kawano, Motohisa Yamamoto, Takako Saeki, Shoko Matsui, Takayuki Sumida, Tsuneyo Mimori, Yoshiya Tanaka, Kazuo Tsubota, Tadashi Yoshino, Shigeyuki Kawa, Ritsuro Suzuki, Tsutomu Takegami, Naohisa Tomosugi, Nozomu Kurose, Yasuhito Ishigaki, Atsushi Azumi, Masaru KojimaShigeo Nakamura, Dai Inoue, Keita Fujikawa, Hideaki Hamano, Keiji Kubo, Hiroshi Yamamoto, Mitsuyosi Hirokawa, Kunihiko Itoh, Terumi Kamisawa, Daisuke Kawabata, Morio Matsumoto, Seijiro Minamoto, Kayoko Murayama, Susumu Nishiyama, Yoko Ogawa, Tomoki Origuchi, Norihide Oyama, Yasuharu Sato, Masao Seto, Susumu Sugai, Norifumi Tsukamoto, Masayuki Takahira, Hiroki Takahashi, Hiroto Tsuboi, Yuko Waseda, Kazuko Kitagawa, Takayuki Nojima, Hitoshi Yokoyama, Hisao Tonami, Toshihiro Fukushima, Masao Tanaka, Yoshimasa Fujita, Toshioki Sawaki, Takafumi Kawanami, Miyuki Miki, Haruka Iwao, Akio Nakajima, Takuji Nakamura

Research output: Contribution to journal › Review article › peer-review

701 Citations (Scopus)

Abstract

IgG4-related disease (IgG4RD) is a novel clinical disease entity characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration by IgG4-positive plasma cells. IgG4RD may be present in a certain proportion of patients with a wide variety of diseases, including Mikulicz's disease, autoimmune pancreatitis, hypophysitis, Riedel thyroiditis, interstitial pneumonitis, interstitial nephritis, prostatitis, lymphadenopathy, retroperitoneal fibrosis, inflammatory aortic aneurysm, and inflammatory pseudotumor. Although IgG4RD forms a distinct, clinically independent disease category and is attracting strong attention as a new clinical entity, many questions and problems still remain to be elucidated, including its pathogenesis, the establishment of diagnostic criteria, and the role of IgG4. Here we describe the concept of IgG4RD and up-to-date information on this emerging disease entity.

Original language	English
Pages (from-to)	1-14
Number of pages	14
Journal	Modern Rheumatology
Volume	22
Issue number	1
DOIs	https://doi.org/10.1007/s10165-011-0508-6
Publication status	Published - Feb 2012

Keywords

Autoimmune pancreatitis
Castleman's disease
IgG4-related diseases
Mikulicz's disease
Sjögren's syndrome

ASJC Scopus subject areas

Rheumatology

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10.1007/s10165-011-0508-6

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Umehara, H., Okazaki, K., Masaki, Y., Kawano, M., Yamamoto, M., Saeki, T., Matsui, S., Sumida, T., Mimori, T., Tanaka, Y., Tsubota, K., Yoshino, T., Kawa, S., Suzuki, R., Takegami, T., Tomosugi, N., Kurose, N., Ishigaki, Y., Azumi, A., ... Nakamura, T. (2012). A novel clinical entity, IgG4-relateddisease (IgG4RD): General concept and details. Modern Rheumatology, 22(1), 1-14. https://doi.org/10.1007/s10165-011-0508-6

Umehara, H, Okazaki, K, Masaki, Y, Kawano, M, Yamamoto, M, Saeki, T, Matsui, S, Sumida, T, Mimori, T, Tanaka, Y, Tsubota, K, Yoshino, T, Kawa, S, Suzuki, R, Takegami, T, Tomosugi, N, Kurose, N, Ishigaki, Y, Azumi, A, Kojima, M, Nakamura, S, Inoue, D, Fujikawa, K, Hamano, H, Kubo, K, Yamamoto, H, Hirokawa, M, Itoh, K, Kamisawa, T, Kawabata, D, Matsumoto, M, Minamoto, S, Murayama, K, Nishiyama, S, Ogawa, Y, Origuchi, T, Oyama, N, Sato, Y, Seto, M, Sugai, S, Tsukamoto, N, Takahira, M, Takahashi, H, Tsuboi, H, Waseda, Y, Kitagawa, K, Nojima, T, Yokoyama, H, Tonami, H, Fukushima, T, Tanaka, M, Fujita, Y, Sawaki, T, Kawanami, T, Miki, M, Iwao, H, Nakajima, A & Nakamura, T 2012, 'A novel clinical entity, IgG4-relateddisease (IgG4RD): General concept and details', Modern Rheumatology, vol. 22, no. 1, pp. 1-14. https://doi.org/10.1007/s10165-011-0508-6

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abstract = "IgG4-related disease (IgG4RD) is a novel clinical disease entity characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration by IgG4-positive plasma cells. IgG4RD may be present in a certain proportion of patients with a wide variety of diseases, including Mikulicz's disease, autoimmune pancreatitis, hypophysitis, Riedel thyroiditis, interstitial pneumonitis, interstitial nephritis, prostatitis, lymphadenopathy, retroperitoneal fibrosis, inflammatory aortic aneurysm, and inflammatory pseudotumor. Although IgG4RD forms a distinct, clinically independent disease category and is attracting strong attention as a new clinical entity, many questions and problems still remain to be elucidated, including its pathogenesis, the establishment of diagnostic criteria, and the role of IgG4. Here we describe the concept of IgG4RD and up-to-date information on this emerging disease entity.",

keywords = "Autoimmune pancreatitis, Castleman's disease, IgG4-related diseases, Mikulicz's disease, Sj{\"o}gren's syndrome",

author = "Hisanori Umehara and Kazuichi Okazaki and Yasufumi Masaki and Mitsuhiro Kawano and Motohisa Yamamoto and Takako Saeki and Shoko Matsui and Takayuki Sumida and Tsuneyo Mimori and Yoshiya Tanaka and Kazuo Tsubota and Tadashi Yoshino and Shigeyuki Kawa and Ritsuro Suzuki and Tsutomu Takegami and Naohisa Tomosugi and Nozomu Kurose and Yasuhito Ishigaki and Atsushi Azumi and Masaru Kojima and Shigeo Nakamura and Dai Inoue and Keita Fujikawa and Hideaki Hamano and Keiji Kubo and Hiroshi Yamamoto and Mitsuyosi Hirokawa and Kunihiko Itoh and Terumi Kamisawa and Daisuke Kawabata and Morio Matsumoto and Seijiro Minamoto and Kayoko Murayama and Susumu Nishiyama and Yoko Ogawa and Tomoki Origuchi and Norihide Oyama and Yasuharu Sato and Masao Seto and Susumu Sugai and Norifumi Tsukamoto and Masayuki Takahira and Hiroki Takahashi and Hiroto Tsuboi and Yuko Waseda and Kazuko Kitagawa and Takayuki Nojima and Hitoshi Yokoyama and Hisao Tonami and Toshihiro Fukushima and Masao Tanaka and Yoshimasa Fujita and Toshioki Sawaki and Takafumi Kawanami and Miyuki Miki and Haruka Iwao and Akio Nakajima and Takuji Nakamura",

note = "Funding Information: Acknowledgments This work was supported by the Research Program for Intractable Diseases, Health and Labor Sciences Research Grants from the Ministry of Health, Labor and Welfare, Japan. We sincerely thank the many contributing researchers and collaborators who participated in the MHLW Japan G4 team.",

year = "2012",

month = feb,

doi = "10.1007/s10165-011-0508-6",

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AU - Masaki, Yasufumi

AU - Kawano, Mitsuhiro

AU - Yamamoto, Motohisa

AU - Saeki, Takako

AU - Matsui, Shoko

AU - Sumida, Takayuki

AU - Mimori, Tsuneyo

AU - Tanaka, Yoshiya

AU - Tsubota, Kazuo

AU - Yoshino, Tadashi

AU - Kawa, Shigeyuki

AU - Suzuki, Ritsuro

AU - Takegami, Tsutomu

AU - Tomosugi, Naohisa

AU - Kurose, Nozomu

AU - Ishigaki, Yasuhito

AU - Azumi, Atsushi

AU - Kojima, Masaru

AU - Nakamura, Shigeo

AU - Inoue, Dai

AU - Fujikawa, Keita

AU - Hamano, Hideaki

AU - Kubo, Keiji

AU - Yamamoto, Hiroshi

AU - Hirokawa, Mitsuyosi

AU - Itoh, Kunihiko

AU - Kamisawa, Terumi

AU - Kawabata, Daisuke

AU - Matsumoto, Morio

AU - Minamoto, Seijiro

AU - Murayama, Kayoko

AU - Nishiyama, Susumu

AU - Ogawa, Yoko

AU - Origuchi, Tomoki

AU - Oyama, Norihide

AU - Sato, Yasuharu

AU - Seto, Masao

AU - Sugai, Susumu

AU - Tsukamoto, Norifumi

AU - Takahira, Masayuki

AU - Takahashi, Hiroki

AU - Tsuboi, Hiroto

AU - Waseda, Yuko

AU - Kitagawa, Kazuko

AU - Nojima, Takayuki

AU - Yokoyama, Hitoshi

AU - Tonami, Hisao

AU - Fukushima, Toshihiro

AU - Tanaka, Masao

AU - Fujita, Yoshimasa

AU - Sawaki, Toshioki

AU - Kawanami, Takafumi

AU - Miki, Miyuki

AU - Iwao, Haruka

AU - Nakajima, Akio

AU - Nakamura, Takuji

N1 - Funding Information: Acknowledgments This work was supported by the Research Program for Intractable Diseases, Health and Labor Sciences Research Grants from the Ministry of Health, Labor and Welfare, Japan. We sincerely thank the many contributing researchers and collaborators who participated in the MHLW Japan G4 team.

PY - 2012/2

Y1 - 2012/2

N2 - IgG4-related disease (IgG4RD) is a novel clinical disease entity characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration by IgG4-positive plasma cells. IgG4RD may be present in a certain proportion of patients with a wide variety of diseases, including Mikulicz's disease, autoimmune pancreatitis, hypophysitis, Riedel thyroiditis, interstitial pneumonitis, interstitial nephritis, prostatitis, lymphadenopathy, retroperitoneal fibrosis, inflammatory aortic aneurysm, and inflammatory pseudotumor. Although IgG4RD forms a distinct, clinically independent disease category and is attracting strong attention as a new clinical entity, many questions and problems still remain to be elucidated, including its pathogenesis, the establishment of diagnostic criteria, and the role of IgG4. Here we describe the concept of IgG4RD and up-to-date information on this emerging disease entity.

AB - IgG4-related disease (IgG4RD) is a novel clinical disease entity characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration by IgG4-positive plasma cells. IgG4RD may be present in a certain proportion of patients with a wide variety of diseases, including Mikulicz's disease, autoimmune pancreatitis, hypophysitis, Riedel thyroiditis, interstitial pneumonitis, interstitial nephritis, prostatitis, lymphadenopathy, retroperitoneal fibrosis, inflammatory aortic aneurysm, and inflammatory pseudotumor. Although IgG4RD forms a distinct, clinically independent disease category and is attracting strong attention as a new clinical entity, many questions and problems still remain to be elucidated, including its pathogenesis, the establishment of diagnostic criteria, and the role of IgG4. Here we describe the concept of IgG4RD and up-to-date information on this emerging disease entity.

KW - Autoimmune pancreatitis

KW - Castleman's disease

KW - IgG4-related diseases

KW - Mikulicz's disease

KW - Sjögren's syndrome

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A novel clinical entity, IgG4-relateddisease (IgG4RD): General concept and details

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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