A novel high-Throughput3D screening system for EMT inhibitors: A pilot screening discovered the EMT inhibitory activity of CDK2 inhibitor SU9516

Medicine & Life Sciences

• SU 9516 100%
• Cyclin-Dependent Kinase 2 64%
• Epithelial-Mesenchymal Transition 47%
• 6-(2-tert-butyl-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline 27%
• 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide 21%
• Hypoxia 10%
• Inhibitory Concentration 50 8%
• Preclinical Drug Evaluations 5%
• Neoplasms 4%
• Agar 4%
• Transcriptome 4%
• Gels 3%
• Fluorescence 3%
• Lung Neoplasms 3%
• Cell Culture Techniques 3%
• Cell Survival 3%
• Neoplasm Metastasis 2%
• Messenger RNA 2%
• Pharmaceutical Preparations 1%
• Therapeutics 0%

Chemical Compounds

• High Throughput Screening 48%
• Mander Carbonylation 41%
• IC50 31%
• Probe 27%
• Drug 23%
• Cell Viability 22%
• Fluorescence Intensity 20%
• Plate Like Crystal 17%
• Dose 17%
• Shape 14%
• Molecule 7%

Agriculture & Biology

• cyclin-dependent kinase 58%
• screening 31%
• hypoxia 20%
• neoplasm cells 20%
• inhibitory concentration 50 13%
• drugs 10%
• lung neoplasms 9%
• metastasis 9%
• cells 9%
• cell viability 6%
• adhesion 6%
• image analysis 6%
• cell culture 6%
• therapeutics 5%
• neoplasms 5%
• agar 5%
• fluorescence 5%
• gels 5%
• receptors 5%
• gene expression 4%
• dosage 3%