A patient with type 3 autoimmune polyglandular syndrome who developed systemic lupus erythematosus 8 years after the diagnosis of autoimmune hepatitis

Tomoyo Mifune-Morioka; Haruhito A. Uchida; Kazuhiko Fukushima; Mayu Watanabe; Chihiro Ouchi; Koki Mise; Chieko Kawakita; Yuzuki Kano; Akifumi Onishi; Kishio Toma; Jun Eguchi; Nozomu Wada; Fusao Ikeda; Erika Sasaki; Yu Suganami; Masayuki Kishida; Hitoshi Sugiyama; Hiroyuki Okada; Jun Wada

A patient with type 3 autoimmune polyglandular syndrome who developed systemic lupus erythematosus 8 years after the diagnosis of autoimmune hepatitis

Tomoyo Mifune-Morioka, Haruhito A. Uchida, Kazuhiko Fukushima, Mayu Watanabe, Chihiro Ouchi, Koki Mise, Chieko Kawakita, Yuzuki Kano, Akifumi Onishi, Kishio Toma, Jun Eguchi, Nozomu Wada, Fusao Ikeda, Erika Sasaki, Yu Suganami, Masayuki Kishida, Hitoshi Sugiyama, Hiroyuki Okada, Jun Wada

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Abstract

Eight years prior to her present admission, a 61-year-old Japanese woman was diagnosed with autoimmune hepatitis, slowly progressive insulin-dependent diabetes mellitus, and chronic thyroiditis; she had been treated with oral prednisolone (PSL). After she suddenly discontinued PSL, she newly developed systemic lupus erythematosus. A combination therapy of oral PSL and intravenous cyclophosphamide resulted in remission. She was finally diagnosed with autoimmune polyglandular syndrome (APS) type 3 (3A, 3B, 3D), complicated with four different autoimmune diseases. Since patients with type 3 APS may present many manifestations over a long period of time, they should be carefully monitored.

Original language	English
Pages (from-to)	367-372
Number of pages	6
Journal	Acta medica Okayama
Volume	73
Issue number	4
Publication status	Published - 2019

Keywords

Autoimmune hepatitis
Autoimmune polyglandular syndrome type 3
Chronic thyroiditis
Slowly progressive insulin-dependent diabetes mellitus
Systemic lupus erythematosus

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Mifune-Morioka, T., Uchida, H. A., Fukushima, K., Watanabe, M., Ouchi, C., Mise, K., Kawakita, C., Kano, Y., Onishi, A., Toma, K., Eguchi, J., Wada, N., Ikeda, F., Sasaki, E., Suganami, Y., Kishida, M., Sugiyama, H., Okada, H., & Wada, J. (2019). A patient with type 3 autoimmune polyglandular syndrome who developed systemic lupus erythematosus 8 years after the diagnosis of autoimmune hepatitis. Acta medica Okayama, 73(4), 367-372.

Mifune-Morioka, T, Uchida, HA, Fukushima, K, Watanabe, M, Ouchi, C, Mise, K, Kawakita, C, Kano, Y, Onishi, A, Toma, K, Eguchi, J , Wada, N, Ikeda, F, Sasaki, E, Suganami, Y, Kishida, M, Sugiyama, H, Okada, H & Wada, J 2019, 'A patient with type 3 autoimmune polyglandular syndrome who developed systemic lupus erythematosus 8 years after the diagnosis of autoimmune hepatitis', Acta medica Okayama, vol. 73, no. 4, pp. 367-372.

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title = "A patient with type 3 autoimmune polyglandular syndrome who developed systemic lupus erythematosus 8 years after the diagnosis of autoimmune hepatitis",

abstract = "Eight years prior to her present admission, a 61-year-old Japanese woman was diagnosed with autoimmune hepatitis, slowly progressive insulin-dependent diabetes mellitus, and chronic thyroiditis; she had been treated with oral prednisolone (PSL). After she suddenly discontinued PSL, she newly developed systemic lupus erythematosus. A combination therapy of oral PSL and intravenous cyclophosphamide resulted in remission. She was finally diagnosed with autoimmune polyglandular syndrome (APS) type 3 (3A, 3B, 3D), complicated with four different autoimmune diseases. Since patients with type 3 APS may present many manifestations over a long period of time, they should be carefully monitored.",

keywords = "Autoimmune hepatitis, Autoimmune polyglandular syndrome type 3, Chronic thyroiditis, Slowly progressive insulin-dependent diabetes mellitus, Systemic lupus erythematosus",

author = "Tomoyo Mifune-Morioka and Uchida, {Haruhito A.} and Kazuhiko Fukushima and Mayu Watanabe and Chihiro Ouchi and Koki Mise and Chieko Kawakita and Yuzuki Kano and Akifumi Onishi and Kishio Toma and Jun Eguchi and Nozomu Wada and Fusao Ikeda and Erika Sasaki and Yu Suganami and Masayuki Kishida and Hitoshi Sugiyama and Hiroyuki Okada and Jun Wada",

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language = "English",

volume = "73",

pages = "367--372",

journal = "Acta Medica Okayama",

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T1 - A patient with type 3 autoimmune polyglandular syndrome who developed systemic lupus erythematosus 8 years after the diagnosis of autoimmune hepatitis

AU - Mifune-Morioka, Tomoyo

AU - Uchida, Haruhito A.

AU - Fukushima, Kazuhiko

AU - Watanabe, Mayu

AU - Ouchi, Chihiro

AU - Mise, Koki

AU - Kawakita, Chieko

AU - Kano, Yuzuki

AU - Onishi, Akifumi

AU - Toma, Kishio

AU - Eguchi, Jun

AU - Wada, Nozomu

AU - Ikeda, Fusao

AU - Sasaki, Erika

AU - Suganami, Yu

AU - Kishida, Masayuki

AU - Sugiyama, Hitoshi

AU - Okada, Hiroyuki

AU - Wada, Jun

PY - 2019

Y1 - 2019

N2 - Eight years prior to her present admission, a 61-year-old Japanese woman was diagnosed with autoimmune hepatitis, slowly progressive insulin-dependent diabetes mellitus, and chronic thyroiditis; she had been treated with oral prednisolone (PSL). After she suddenly discontinued PSL, she newly developed systemic lupus erythematosus. A combination therapy of oral PSL and intravenous cyclophosphamide resulted in remission. She was finally diagnosed with autoimmune polyglandular syndrome (APS) type 3 (3A, 3B, 3D), complicated with four different autoimmune diseases. Since patients with type 3 APS may present many manifestations over a long period of time, they should be carefully monitored.

AB - Eight years prior to her present admission, a 61-year-old Japanese woman was diagnosed with autoimmune hepatitis, slowly progressive insulin-dependent diabetes mellitus, and chronic thyroiditis; she had been treated with oral prednisolone (PSL). After she suddenly discontinued PSL, she newly developed systemic lupus erythematosus. A combination therapy of oral PSL and intravenous cyclophosphamide resulted in remission. She was finally diagnosed with autoimmune polyglandular syndrome (APS) type 3 (3A, 3B, 3D), complicated with four different autoimmune diseases. Since patients with type 3 APS may present many manifestations over a long period of time, they should be carefully monitored.

KW - Autoimmune hepatitis

KW - Autoimmune polyglandular syndrome type 3

KW - Chronic thyroiditis

KW - Slowly progressive insulin-dependent diabetes mellitus

KW - Systemic lupus erythematosus

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AN - SCOPUS:85071501764

SN - 0386-300X

VL - 73

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EP - 372

JO - Acta Medica Okayama

JF - Acta Medica Okayama

IS - 4

ER -

A patient with type 3 autoimmune polyglandular syndrome who developed systemic lupus erythematosus 8 years after the diagnosis of autoimmune hepatitis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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