A pilot study: Effects of dietary supplementation with α-linolenic acid-enriched perilla seed oil on bronchial asthma

Kozo Ashida; Fumihiro Mitsunobu; Takashi Mifune; Yasuhiro Hosaki; Satoshi Yokota; Hirofumi Tsugeno; Yoshiro Tanizaki; Takao Tsuji

doi:10.2332/allergolint.46.181

A pilot study: Effects of dietary supplementation with α-linolenic acid-enriched perilla seed oil on bronchial asthma

Kozo Ashida, Fumihiro Mitsunobu, Takashi Mifune, Yasuhiro Hosaki, Satoshi Yokota, Hirofumi Tsugeno, Yoshiro Tanizaki, Takao Tsuji

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

N-3 fatty acids, such as fish oil, have been reported to have some beneficial effects in patients with bronchial asthma. The effects of dietary supplementation with perilla seed oil rich in a-linolenic acid (α-LNA), parent n-3 fatty acid, were studied in five patients with asthma. The symptoms of asthma and mean peak flow rates (PFR) both early in the morning and in the evening were improved 2 weeks after dietary supplementation and the increases in PFR were significant (P < 0.05). The generation of leukotriene B₄(LTB₄) by peripheral leukocytes stimulated with the Ca₂₊ionophore A23187 was significantly suppressed from 77.6 to 41.6ng/5X10₆cells by dietary supplementation (P< 0.05). The generation of leukotriene C₄(LTC₄) by leukocytes was also significantly suppressed from 64.0 to 38.8 ng/5x10₆cells after supplementation with perilla seed oil (P < 0.05). These results suggest that dietary supplementation with perilla seed oil is beneficial for the treatment of asthma.

Original language	English
Pages (from-to)	181-185
Number of pages	5
Journal	Allergology International
Volume	46
Issue number	3
DOIs	https://doi.org/10.2332/allergolint.46.181
Publication status	Published - 1997

Keywords

bronchial asthma
leukotriene B
leukotriene C
peak flow
perilla seed oil

ASJC Scopus subject areas

Immunology and Allergy

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10.2332/allergolint.46.181

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title = "A pilot study: Effects of dietary supplementation with α-linolenic acid-enriched perilla seed oil on bronchial asthma",

abstract = "N-3 fatty acids, such as fish oil, have been reported to have some beneficial effects in patients with bronchial asthma. The effects of dietary supplementation with perilla seed oil rich in a-linolenic acid (α-LNA), parent n-3 fatty acid, were studied in five patients with asthma. The symptoms of asthma and mean peak flow rates (PFR) both early in the morning and in the evening were improved 2 weeks after dietary supplementation and the increases in PFR were significant (P < 0.05). The generation of leukotriene B4(LTB4) by peripheral leukocytes stimulated with the Ca2+ionophore A23187 was significantly suppressed from 77.6 to 41.6ng/5X106cells by dietary supplementation (P< 0.05). The generation of leukotriene C4(LTC4) by leukocytes was also significantly suppressed from 64.0 to 38.8 ng/5x106cells after supplementation with perilla seed oil (P < 0.05). These results suggest that dietary supplementation with perilla seed oil is beneficial for the treatment of asthma.",

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author = "Kozo Ashida and Fumihiro Mitsunobu and Takashi Mifune and Yasuhiro Hosaki and Satoshi Yokota and Hirofumi Tsugeno and Yoshiro Tanizaki and Takao Tsuji",

year = "1997",

doi = "10.2332/allergolint.46.181",

language = "English",

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journal = "Allergology International",

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T2 - Effects of dietary supplementation with α-linolenic acid-enriched perilla seed oil on bronchial asthma

AU - Ashida, Kozo

AU - Mitsunobu, Fumihiro

AU - Mifune, Takashi

AU - Hosaki, Yasuhiro

AU - Yokota, Satoshi

AU - Tsugeno, Hirofumi

AU - Tanizaki, Yoshiro

AU - Tsuji, Takao

PY - 1997

Y1 - 1997

N2 - N-3 fatty acids, such as fish oil, have been reported to have some beneficial effects in patients with bronchial asthma. The effects of dietary supplementation with perilla seed oil rich in a-linolenic acid (α-LNA), parent n-3 fatty acid, were studied in five patients with asthma. The symptoms of asthma and mean peak flow rates (PFR) both early in the morning and in the evening were improved 2 weeks after dietary supplementation and the increases in PFR were significant (P < 0.05). The generation of leukotriene B4(LTB4) by peripheral leukocytes stimulated with the Ca2+ionophore A23187 was significantly suppressed from 77.6 to 41.6ng/5X106cells by dietary supplementation (P< 0.05). The generation of leukotriene C4(LTC4) by leukocytes was also significantly suppressed from 64.0 to 38.8 ng/5x106cells after supplementation with perilla seed oil (P < 0.05). These results suggest that dietary supplementation with perilla seed oil is beneficial for the treatment of asthma.

AB - N-3 fatty acids, such as fish oil, have been reported to have some beneficial effects in patients with bronchial asthma. The effects of dietary supplementation with perilla seed oil rich in a-linolenic acid (α-LNA), parent n-3 fatty acid, were studied in five patients with asthma. The symptoms of asthma and mean peak flow rates (PFR) both early in the morning and in the evening were improved 2 weeks after dietary supplementation and the increases in PFR were significant (P < 0.05). The generation of leukotriene B4(LTB4) by peripheral leukocytes stimulated with the Ca2+ionophore A23187 was significantly suppressed from 77.6 to 41.6ng/5X106cells by dietary supplementation (P< 0.05). The generation of leukotriene C4(LTC4) by leukocytes was also significantly suppressed from 64.0 to 38.8 ng/5x106cells after supplementation with perilla seed oil (P < 0.05). These results suggest that dietary supplementation with perilla seed oil is beneficial for the treatment of asthma.

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KW - leukotriene B

KW - leukotriene C

KW - peak flow

KW - perilla seed oil

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A pilot study: Effects of dietary supplementation with α-linolenic acid-enriched perilla seed oil on bronchial asthma

Abstract

Keywords

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