A possible role for calmodulin in Ca2+-induced swelling of mitochondria

O. Hatase; T. Itano; H. Matsui; A. Doi; S. Etoh; H. Nishio; S. Nakahara

A possible role for calmodulin in Ca²⁺-induced swelling of mitochondria

O. Hatase, T. Itano, H. Matsui, A. Doi, S. Etoh, H. Nishio, S. Nakahara

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

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Abstract

Ca²⁺-induced mitochondrial swelling was inhibited by a low concentration of calmodulin antagonists. Two affinities of Ca²⁺ to mitochondrial swelling were observed: high (2-5 μM) and low (more than 100 μM) systems. The high-affinity change was inhibited by micromolar level of trifluoperazine and W-7, but not by W-5. The possible mechanism of this inhibition and the role of CaM in mitochondria are discussed.

Original language	English
Pages (from-to)	793-799
Number of pages	7
Journal	Biochemistry International
Volume	15
Issue number	4
Publication status	Published - Dec 1 1987

ASJC Scopus subject areas

Biochemistry

Cite this

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abstract = "Ca2+-induced mitochondrial swelling was inhibited by a low concentration of calmodulin antagonists. Two affinities of Ca2+ to mitochondrial swelling were observed: high (2-5 μM) and low (more than 100 μM) systems. The high-affinity change was inhibited by micromolar level of trifluoperazine and W-7, but not by W-5. The possible mechanism of this inhibition and the role of CaM in mitochondria are discussed.",

author = "O. Hatase and T. Itano and H. Matsui and A. Doi and S. Etoh and H. Nishio and S. Nakahara",

year = "1987",

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T1 - A possible role for calmodulin in Ca2+-induced swelling of mitochondria

AU - Hatase, O.

AU - Itano, T.

AU - Matsui, H.

AU - Doi, A.

AU - Etoh, S.

AU - Nishio, H.

AU - Nakahara, S.

PY - 1987/12/1

Y1 - 1987/12/1

N2 - Ca2+-induced mitochondrial swelling was inhibited by a low concentration of calmodulin antagonists. Two affinities of Ca2+ to mitochondrial swelling were observed: high (2-5 μM) and low (more than 100 μM) systems. The high-affinity change was inhibited by micromolar level of trifluoperazine and W-7, but not by W-5. The possible mechanism of this inhibition and the role of CaM in mitochondria are discussed.

AB - Ca2+-induced mitochondrial swelling was inhibited by a low concentration of calmodulin antagonists. Two affinities of Ca2+ to mitochondrial swelling were observed: high (2-5 μM) and low (more than 100 μM) systems. The high-affinity change was inhibited by micromolar level of trifluoperazine and W-7, but not by W-5. The possible mechanism of this inhibition and the role of CaM in mitochondria are discussed.

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JO - Biochemistry International

JF - Biochemistry International

IS - 4

ER -

A possible role for calmodulin in Ca²⁺-induced swelling of mitochondria

Abstract

ASJC Scopus subject areas

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