A preclinical in vivo investigation of high-intensity focused ultrasound combined with radiotherapy

Chao Xing Liu; Xian Shu Gao; Liu Lin Xiong; Hui Yu Ge; Xin Yong He; Ting Li; Hong Juan Zhang; Hong Zhong Bai; Qiang Lin; Ming Zhang; Jing Zhao; Wei Xiong; Yu Bai; Junichi Asaumi

doi:10.1016/j.ultrasmedbio.2010.10.001

A preclinical in vivo investigation of high-intensity focused ultrasound combined with radiotherapy

Chao Xing Liu, Xian Shu Gao, Liu Lin Xiong, Hui Yu Ge, Xin Yong He, Ting Li, Hong Juan Zhang, Hong Zhong Bai, Qiang Lin, Ming Zhang, Jing Zhao, Wei Xiong, Yu Bai, Junichi Asaumi

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

This study aims to perform an in vivo investigation evaluating the injury to the pancreas and adjacent tissue of swine resulting with high-intensity focused ultrasound (HIFU) combined with radiotherapy (RT). The protocol was approved by the animal ethics committee at the Peking University First Hospital. A total of 12 domestic swine were divided into four groups: control, HIFU only, RT only and HIFU + RT. The injury to the pancreas, adjacent tissue and tissue within the acoustic path of the HIFU beam was assessed based on gross and histologic findings. For the targeted region of the pancreas, the score of the combined group was higher than that of the HIFU group and there was significant difference. For the acoustic path tissue, there was no significant difference except between the control group and the other groups. HIFU combined with RT increased the injury to the targeted pancreas, without increased injury to tissue outside of the targeted region.

Original language	English
Pages (from-to)	69-77
Number of pages	9
Journal	Ultrasound in Medicine and Biology
Volume	37
Issue number	1
DOIs	https://doi.org/10.1016/j.ultrasmedbio.2010.10.001
Publication status	Published - Jan 2011

Keywords

High-intensity focused ultrasound (HIFU)
Injury
Pancreas
Radiotherapy (RT)
Swine

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Biophysics
Acoustics and Ultrasonics

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10.1016/j.ultrasmedbio.2010.10.001

Cite this

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title = "A preclinical in vivo investigation of high-intensity focused ultrasound combined with radiotherapy",

abstract = "This study aims to perform an in vivo investigation evaluating the injury to the pancreas and adjacent tissue of swine resulting with high-intensity focused ultrasound (HIFU) combined with radiotherapy (RT). The protocol was approved by the animal ethics committee at the Peking University First Hospital. A total of 12 domestic swine were divided into four groups: control, HIFU only, RT only and HIFU + RT. The injury to the pancreas, adjacent tissue and tissue within the acoustic path of the HIFU beam was assessed based on gross and histologic findings. For the targeted region of the pancreas, the score of the combined group was higher than that of the HIFU group and there was significant difference. For the acoustic path tissue, there was no significant difference except between the control group and the other groups. HIFU combined with RT increased the injury to the targeted pancreas, without increased injury to tissue outside of the targeted region.",

keywords = "High-intensity focused ultrasound (HIFU), Injury, Pancreas, Radiotherapy (RT), Swine",

author = "Liu, {Chao Xing} and Gao, {Xian Shu} and Xiong, {Liu Lin} and Ge, {Hui Yu} and He, {Xin Yong} and Ting Li and Zhang, {Hong Juan} and Bai, {Hong Zhong} and Qiang Lin and Ming Zhang and Jing Zhao and Wei Xiong and Yu Bai and Junichi Asaumi",

note = "Funding Information: The authors would like to acknowledge Ding Rui and Fei Xing Bo for their assistance during the performance of the experiment and Li Xue Ying for her assistance with the data statistics. This study has been supported by a grant from the Ministry of Health of the People{\textquoteright}s Republic of China special funding program (Project ID: WKJ2006-1-007 ).",

year = "2011",

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doi = "10.1016/j.ultrasmedbio.2010.10.001",

language = "English",

volume = "37",

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AU - Liu, Chao Xing

AU - Gao, Xian Shu

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AU - Ge, Hui Yu

AU - He, Xin Yong

AU - Li, Ting

AU - Zhang, Hong Juan

AU - Bai, Hong Zhong

AU - Lin, Qiang

AU - Zhang, Ming

AU - Zhao, Jing

AU - Xiong, Wei

AU - Bai, Yu

AU - Asaumi, Junichi

N1 - Funding Information: The authors would like to acknowledge Ding Rui and Fei Xing Bo for their assistance during the performance of the experiment and Li Xue Ying for her assistance with the data statistics. This study has been supported by a grant from the Ministry of Health of the People’s Republic of China special funding program (Project ID: WKJ2006-1-007 ).

PY - 2011/1

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N2 - This study aims to perform an in vivo investigation evaluating the injury to the pancreas and adjacent tissue of swine resulting with high-intensity focused ultrasound (HIFU) combined with radiotherapy (RT). The protocol was approved by the animal ethics committee at the Peking University First Hospital. A total of 12 domestic swine were divided into four groups: control, HIFU only, RT only and HIFU + RT. The injury to the pancreas, adjacent tissue and tissue within the acoustic path of the HIFU beam was assessed based on gross and histologic findings. For the targeted region of the pancreas, the score of the combined group was higher than that of the HIFU group and there was significant difference. For the acoustic path tissue, there was no significant difference except between the control group and the other groups. HIFU combined with RT increased the injury to the targeted pancreas, without increased injury to tissue outside of the targeted region.

AB - This study aims to perform an in vivo investigation evaluating the injury to the pancreas and adjacent tissue of swine resulting with high-intensity focused ultrasound (HIFU) combined with radiotherapy (RT). The protocol was approved by the animal ethics committee at the Peking University First Hospital. A total of 12 domestic swine were divided into four groups: control, HIFU only, RT only and HIFU + RT. The injury to the pancreas, adjacent tissue and tissue within the acoustic path of the HIFU beam was assessed based on gross and histologic findings. For the targeted region of the pancreas, the score of the combined group was higher than that of the HIFU group and there was significant difference. For the acoustic path tissue, there was no significant difference except between the control group and the other groups. HIFU combined with RT increased the injury to the targeted pancreas, without increased injury to tissue outside of the targeted region.

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A preclinical in vivo investigation of high-intensity focused ultrasound combined with radiotherapy

Abstract

Keywords

ASJC Scopus subject areas

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