A preclinical in vivo investigation of high-intensity focused ultrasound combined with radiotherapy

Chao Xing Liu, Xian Shu Gao, Liu Lin Xiong, Hui Yu Ge, Xin Yong He, Ting Li, Hong Juan Zhang, Hong Zhong Bai, Qiang Lin, Ming Zhang, Jing Zhao, Wei Xiong, Yu Bai, Junichi Asaumi

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


This study aims to perform an in vivo investigation evaluating the injury to the pancreas and adjacent tissue of swine resulting with high-intensity focused ultrasound (HIFU) combined with radiotherapy (RT). The protocol was approved by the animal ethics committee at the Peking University First Hospital. A total of 12 domestic swine were divided into four groups: control, HIFU only, RT only and HIFU + RT. The injury to the pancreas, adjacent tissue and tissue within the acoustic path of the HIFU beam was assessed based on gross and histologic findings. For the targeted region of the pancreas, the score of the combined group was higher than that of the HIFU group and there was significant difference. For the acoustic path tissue, there was no significant difference except between the control group and the other groups. HIFU combined with RT increased the injury to the targeted pancreas, without increased injury to tissue outside of the targeted region.

Original languageEnglish
Pages (from-to)69-77
Number of pages9
JournalUltrasound in Medicine and Biology
Issue number1
Publication statusPublished - Jan 2011


  • High-intensity focused ultrasound (HIFU)
  • Injury
  • Pancreas
  • Radiotherapy (RT)
  • Swine

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics


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