Abstract
Nuclear protein of the testis carcinoma (NUTC) is a rare and aggressive malignancy. We herein report a case of NUTC in the lung characterized by a bronchial lesion and elevated alpha-fetoprotein levels. A 35-year-old Japanese man presented to our institution with suspected advanced lung cancer based on a histological examination. Subsequently, next-generation sequencing (NGS) yielded a positive BRD4-NUTM1 fusion. In addition, positive NUT immunostaining of the lung biopsy specimen confirmed NUTC in the lungs. Systemic chemotherapy and radiotherapy showed a temporary response, with decreased serum alpha-fetoprotein levels. We highlight this case of a prompt diagnosis by NGS of NUTC in a young individual with a rapidly progressing tumor.
Original language | English |
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Pages (from-to) | 2655-2660 |
Number of pages | 6 |
Journal | Internal Medicine |
Volume | 63 |
Issue number | 19 |
DOIs | |
Publication status | Published - 2024 |
Keywords
- alpha-fetoprotein (AFP)
- BRD4-NUTM1
- immune checkpoint inhibitor
- lung cancer
- NUT carcinoma
ASJC Scopus subject areas
- Internal Medicine