A Prompt Diagnosis and Treatment of a Case of Nuclear Protein of the Testis Carcinoma Characterized by a Bronchial Lesion and High Serum Alpha-fetoprotein Level Following Genomic Testing

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Abstract

Nuclear protein of the testis carcinoma (NUTC) is a rare and aggressive malignancy. We herein report a case of NUTC in the lung characterized by a bronchial lesion and elevated alpha-fetoprotein levels. A 35-year-old Japanese man presented to our institution with suspected advanced lung cancer based on a histological examination. Subsequently, next-generation sequencing (NGS) yielded a positive BRD4-NUTM1 fusion. In addition, positive NUT immunostaining of the lung biopsy specimen confirmed NUTC in the lungs. Systemic chemotherapy and radiotherapy showed a temporary response, with decreased serum alpha-fetoprotein levels. We highlight this case of a prompt diagnosis by NGS of NUTC in a young individual with a rapidly progressing tumor.

Original languageEnglish
Pages (from-to)2655-2660
Number of pages6
JournalInternal Medicine
Volume63
Issue number19
DOIs
Publication statusPublished - 2024

Keywords

  • alpha-fetoprotein (AFP)
  • BRD4-NUTM1
  • immune checkpoint inhibitor
  • lung cancer
  • NUT carcinoma

ASJC Scopus subject areas

  • Internal Medicine

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