A purification system for 64Cu produced by a biomedical cyclotron for antibody PET imaging

Teruaki Toyota; Tadashi Hanafusa; Takashi Oda; Iwane Koumura; Takanori Sasaki; Eiji Matsuura; Hiromi Kumon; Tsuneo Yano; Toshiro Ono

doi:10.1007/s10967-012-2340-7

A purification system for ⁶⁴Cu produced by a biomedical cyclotron for antibody PET imaging

Teruaki Toyota, Tadashi Hanafusa, Takashi Oda, Iwane Koumura, Takanori Sasaki, Eiji Matsuura, Hiromi Kumon, Tsuneo Yano, Toshiro Ono

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Ion exchange is a simple and efficient method for separating no-carrier-added ⁶⁴Cu from an irradiated Ni target. We developed a semi-automated two-round ⁶⁴Cu separation system equipped with a strong-base anion exchange resin column. We first verified the efficiency of the system using a non-radioactive substitute consisting of 25 mg of Ni and 127 ng of Cu, and confirmed that Cu was completely eluted at the second round of the separation step. After the bombardment, separation of ⁶⁴Cu from the Ni target was achieved with high radiochemical purity. ⁶⁴Cu produced and separated in this study had an extremely low level of Ni impurity. It could be used for labeling monoclonal antibodies for antibody positron emission tomography imaging and synthesizing radiopharmaceuticals.

Original language	English
Pages (from-to)	295-300
Number of pages	6
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	298
Issue number	1
DOIs	https://doi.org/10.1007/s10967-012-2340-7
Publication status	Published - Oct 2013

Keywords

Anion exchange chromatography
Atomic absorption spectrometry
Cyclotron
Positron emission tomography (PET)

ASJC Scopus subject areas

Analytical Chemistry
Nuclear Energy and Engineering
Radiology Nuclear Medicine and imaging
Pollution
Spectroscopy
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s10967-012-2340-7

Cite this

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title = "A purification system for 64Cu produced by a biomedical cyclotron for antibody PET imaging",

abstract = "Ion exchange is a simple and efficient method for separating no-carrier-added 64Cu from an irradiated Ni target. We developed a semi-automated two-round 64Cu separation system equipped with a strong-base anion exchange resin column. We first verified the efficiency of the system using a non-radioactive substitute consisting of 25 mg of Ni and 127 ng of Cu, and confirmed that Cu was completely eluted at the second round of the separation step. After the bombardment, separation of 64Cu from the Ni target was achieved with high radiochemical purity. 64Cu produced and separated in this study had an extremely low level of Ni impurity. It could be used for labeling monoclonal antibodies for antibody positron emission tomography imaging and synthesizing radiopharmaceuticals.",

keywords = "Anion exchange chromatography, Atomic absorption spectrometry, Cyclotron, Positron emission tomography (PET)",

author = "Teruaki Toyota and Tadashi Hanafusa and Takashi Oda and Iwane Koumura and Takanori Sasaki and Eiji Matsuura and Hiromi Kumon and Tsuneo Yano and Toshiro Ono",

note = "Funding Information: Acknowledgments We thank Mr. H. Okamoto and Mr. S. Iwasa (Central Research Laboratory, Okayama University Medical School) for atomic absorption spectrometry. We also thank Dr. T. Nagamatsu (Advanced Science Research Center, Okayama University) for excellent technical assistance and Mrs. T. Terada for preparation of the manuscript. This work was supported in part by Japan Science and Technology Agency.",

year = "2013",

month = oct,

doi = "10.1007/s10967-012-2340-7",

language = "English",

volume = "298",

pages = "295--300",

journal = "Journal of Radioanalytical Chemistry",

issn = "0022-4081",

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number = "1",

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T1 - A purification system for 64Cu produced by a biomedical cyclotron for antibody PET imaging

AU - Toyota, Teruaki

AU - Hanafusa, Tadashi

AU - Oda, Takashi

AU - Koumura, Iwane

AU - Sasaki, Takanori

AU - Matsuura, Eiji

AU - Kumon, Hiromi

AU - Yano, Tsuneo

AU - Ono, Toshiro

N1 - Funding Information: Acknowledgments We thank Mr. H. Okamoto and Mr. S. Iwasa (Central Research Laboratory, Okayama University Medical School) for atomic absorption spectrometry. We also thank Dr. T. Nagamatsu (Advanced Science Research Center, Okayama University) for excellent technical assistance and Mrs. T. Terada for preparation of the manuscript. This work was supported in part by Japan Science and Technology Agency.

PY - 2013/10

Y1 - 2013/10

N2 - Ion exchange is a simple and efficient method for separating no-carrier-added 64Cu from an irradiated Ni target. We developed a semi-automated two-round 64Cu separation system equipped with a strong-base anion exchange resin column. We first verified the efficiency of the system using a non-radioactive substitute consisting of 25 mg of Ni and 127 ng of Cu, and confirmed that Cu was completely eluted at the second round of the separation step. After the bombardment, separation of 64Cu from the Ni target was achieved with high radiochemical purity. 64Cu produced and separated in this study had an extremely low level of Ni impurity. It could be used for labeling monoclonal antibodies for antibody positron emission tomography imaging and synthesizing radiopharmaceuticals.

AB - Ion exchange is a simple and efficient method for separating no-carrier-added 64Cu from an irradiated Ni target. We developed a semi-automated two-round 64Cu separation system equipped with a strong-base anion exchange resin column. We first verified the efficiency of the system using a non-radioactive substitute consisting of 25 mg of Ni and 127 ng of Cu, and confirmed that Cu was completely eluted at the second round of the separation step. After the bombardment, separation of 64Cu from the Ni target was achieved with high radiochemical purity. 64Cu produced and separated in this study had an extremely low level of Ni impurity. It could be used for labeling monoclonal antibodies for antibody positron emission tomography imaging and synthesizing radiopharmaceuticals.

KW - Anion exchange chromatography

KW - Atomic absorption spectrometry

KW - Cyclotron

KW - Positron emission tomography (PET)

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