A randomized study of two long-course prednisolone regimens for nephrotic syndrome in children

Masahiro Hiraoka, Hirokazu Tsukahara, Kousaku Matsubara, Masahito Tsurusawa, Nobuaki Takeda, Shinichi Haruki, Shuhei Hayashi, Kazuhide Ohta, Tohru Momoi, Yusei Ohshima, Narufumi Suganuma, Mitsufumi Mayumi

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59 Citations (Scopus)


Background: Long-course prednisolone regimens have been shown to be more effective than short-course regimens in sustaining remission of nephrotic syndrome in children. However, the most beneficial approach among the long-course regimens remains unknown. Methods: Seventy-three children with new-onset nephrotic syndrome were allocated at random to the two long-course regimens and followed up for 2 years. Group A was administered prednisolone at a daily dose of 60 mg/m2 for 6 weeks, followed by an alternate-day dose of 40 mg/m2 for 6 weeks (the long daily regimen). Group B was administered the same daily dose for 4 weeks, followed by an alternate-day dose of 60 mg/m2 for 4 weeks, and doses were tapered by 10 mg/m2 every 4 weeks (the long alternate-day regimen). Results: Group B had a lower incidence of corticosteroid toxicities than group A during the initial treatment. Kaplan-Meier analysis of the sustained remission rate of the two treatment groups showed a marginally significant difference (P = 0.069) and showed a significant difference when patients were stratified for age of disease onset (P = 0.048). In a subgroup of younger children (<4 years at onset), group B had a greater rate of sustained remission (P < 0.01) and fewer children with frequent relapses (P < 0.05) than group A, whereas in older children (≥4 years at onset), both groups had similar good sustained remission rates. Conclusion: These findings collectively indicate that the long alternate-day regimen may be more beneficial, with less corticosterold toxicities, than the long daily regimen, and children with younger age at disease onset may be susceptible to relapse and especially benefit from the long alternate-day regimen for sustaining remission of the disease.

Original languageEnglish
Pages (from-to)1155-1162
Number of pages8
JournalAmerican Journal of Kidney Diseases
Issue number6
Publication statusPublished - Jun 1 2003
Externally publishedYes


  • Children
  • Corticosterold toxicities
  • Frequent relapser
  • Nephrotic syndrome
  • Prednisolone
  • Randomized, controlled study

ASJC Scopus subject areas

  • Nephrology


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