TY - JOUR
T1 - A single-nucleotide polymorphism in a gene modulating glucocorticoid sensitivity is associated with the decline in total lung capacity after lung transplantation
AU - Yamamoto, Haruchika
AU - Sugimoto, Seiichiro
AU - Tanaka, Shin
AU - Kurosaki, Takeshi
AU - Otani, Shinji
AU - Yamane, Masaomi
AU - Taira, Naruto
AU - Oto, Takahiro
AU - Toyooka, Shinichi
N1 - Funding Information:
Funding This work was supported by a Grant-in-Aid for Scientific Research grant no. 15K10256 from the Japan Society for the Promotion of Science.
Publisher Copyright:
© 2018, Springer Nature Singapore Pte Ltd.
PY - 2019/3/8
Y1 - 2019/3/8
N2 - Purpose: Glucocorticoids are used to prevent chronic lung allograft dysfunction (CLAD) after lung transplantation (LT). Our study was aimed at assessing the association between the glucocorticoid-induced transcript 1 gene (GLCCI1) variant, which modulates glucocorticoid sensitivity, and the postoperative lung function and development of CLAD after LT. Methods: A total of 71 recipients of LT were genotyped for the GLCCI1 variant (rs37972) and divided into three groups: the homozygous mutant allele (TT) group, the heterozygous mutant allele (CT) group, and the wild-type allele (CC) group. The results of pulmonary function tests were compared with the postoperative baseline values. Results: The total lung capacity (TLC) in the TT group was significantly lower than that in the CC group at 3 years after LT (P = 0.029). In the recipients of cadaveric LT, the TLC and forced expiratory volume in 1 s in the TT group were significantly lower than those in the CC groups, resulting in a significant worse CLAD-free survival at 3 years after LT (P = 0.016). Conclusion: The GLCCI1 variant was associated with a significant decrease of the TLC at 3 years after LT and the development of CLAD at 3 years, especially in patients undergoing cadaveric LT.
AB - Purpose: Glucocorticoids are used to prevent chronic lung allograft dysfunction (CLAD) after lung transplantation (LT). Our study was aimed at assessing the association between the glucocorticoid-induced transcript 1 gene (GLCCI1) variant, which modulates glucocorticoid sensitivity, and the postoperative lung function and development of CLAD after LT. Methods: A total of 71 recipients of LT were genotyped for the GLCCI1 variant (rs37972) and divided into three groups: the homozygous mutant allele (TT) group, the heterozygous mutant allele (CT) group, and the wild-type allele (CC) group. The results of pulmonary function tests were compared with the postoperative baseline values. Results: The total lung capacity (TLC) in the TT group was significantly lower than that in the CC group at 3 years after LT (P = 0.029). In the recipients of cadaveric LT, the TLC and forced expiratory volume in 1 s in the TT group were significantly lower than those in the CC groups, resulting in a significant worse CLAD-free survival at 3 years after LT (P = 0.016). Conclusion: The GLCCI1 variant was associated with a significant decrease of the TLC at 3 years after LT and the development of CLAD at 3 years, especially in patients undergoing cadaveric LT.
KW - Chronic lung allograft dysfunction
KW - Glucocorticoid
KW - Lung transplantation
KW - Single-nucleotide polymorphism
KW - Total lung capacity
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U2 - 10.1007/s00595-018-1717-9
DO - 10.1007/s00595-018-1717-9
M3 - Article
C2 - 30229311
AN - SCOPUS:85053491600
SN - 0941-1291
VL - 49
SP - 268
EP - 274
JO - Japanese Journal of Surgery
JF - Japanese Journal of Surgery
IS - 3
ER -