TY - JOUR
T1 - A study of the hydrophilic cellulose matrix
T2 - Effect of indomethacin and a water-soluble additive on swelling properties
AU - Panomsuk, Suwannee P.
AU - Hatanaka, Tomomi
AU - Aiba, Tetsuya
AU - Katayama, Kazunori
AU - Koizumi, Tamotsu
PY - 1995/12/29
Y1 - 1995/12/29
N2 - A swelling measurement device was designed to observe the axial swelling direction of a matrix containing various types of hydrophilic cellulose derivatives (methylcellulose, hydroxypropylmethylcellulose and hydroxypropylcellulose). The effect of indomethacin and lactose on the swelling properties was also studied. The maximum swelling index and the apparent diffusion coefficient of water in the matrix, calculated from the swelling data, were used to describe the swelling properties of the matrix, reflecting the matrix integrity. The results showed that hydroxypropylcellulose produced a matrix with a high integrity. Indomethacin and lactose changed the swelling properties of the hydrophilic cellulose matrices in this study.
AB - A swelling measurement device was designed to observe the axial swelling direction of a matrix containing various types of hydrophilic cellulose derivatives (methylcellulose, hydroxypropylmethylcellulose and hydroxypropylcellulose). The effect of indomethacin and lactose on the swelling properties was also studied. The maximum swelling index and the apparent diffusion coefficient of water in the matrix, calculated from the swelling data, were used to describe the swelling properties of the matrix, reflecting the matrix integrity. The results showed that hydroxypropylcellulose produced a matrix with a high integrity. Indomethacin and lactose changed the swelling properties of the hydrophilic cellulose matrices in this study.
KW - Apparent diffusion coefficient
KW - Hydrophilic cellulose matrix
KW - Indomethacin
KW - Mathematical model
KW - Maximum swelling index
KW - Swelling properties
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U2 - 10.1016/0378-5173(95)04113-3
DO - 10.1016/0378-5173(95)04113-3
M3 - Article
AN - SCOPUS:0029617760
SN - 0378-5173
VL - 126
SP - 147
EP - 153
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 1-2
ER -