Abstract
A novel taxane with an unprecedented hemiacetal ring between C-13 and C-9 was isolated from the needles of Taxus cuspidata. The structure was characterized as (12αH)-2α,10β-diacetoxy-5α-cinnamoyloxy-9α,13α-epoxytax-4(20)-ene-11β,13β-diol (1). This is the first example of a natural taxane with a C-13 and C-9 oxygen bridge to form an unusual 6/8/6/6-membered ring system.
Original language | English |
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Pages (from-to) | 1180-1183 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 49 |
Issue number | 7 |
DOIs | |
Publication status | Published - Feb 11 2008 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry