A unique case with positive anti-myelin oligodendrocyte glycoprotein antibody presenting multiple brain lesions

Namiko Matsumoto; Kota Sato; Nozomi Hishikawa; Yuko Kawahara; Mami Takemoto; Yasuyuki Ohta; Toru Yamashita; Kentaro Fujii; Kazuhiko Kurozumi; Isao Date; Toshiyuki Takahashi; Koji Abe

doi:10.1111/ncn3.12364

A unique case with positive anti-myelin oligodendrocyte glycoprotein antibody presenting multiple brain lesions

Namiko Matsumoto
, Kota Sato
, Nozomi Hishikawa
, Yuko Kawahara
, Mami Takemoto
, Yasuyuki Ohta
, Toru Yamashita
, Kentaro Fujii
, Kazuhiko Kurozumi
, Isao Date
, Toshiyuki Takahashi
, Koji Abe

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The accurate diagnosis of anti-myelin oligodendrocyte glycoprotein (MOG) antibody-associated diseases is sometimes challenging due to its various central nervous system (CNS) lesions. Here, we report a 22-year-old man with positive anti-MOG antibody presenting multiple brain lesions including a brainstem tumefactive demyelinating lesion (TDL), cortical edematous lesions, and a periventricular white matter lesion. These variety of lesions made the diagnosis challenging, especially because TDL is quite rare among MOG antibody-associated disease patients. The present case suggests the importance to check anti-MOG antibody for patients presenting atypical multiple CNS lesions.

Original language	English
Pages (from-to)	92-95
Number of pages	4
Journal	Neurology and Clinical Neuroscience
Volume	8
Issue number	2
DOIs	https://doi.org/10.1111/ncn3.12364
Publication status	Published - Mar 1 2020

Keywords

clinically isolated syndrome
MS and related diseases
myelin oligodendrocyte glycoprotein
neuromyelitis optica spectrum disorder
tumefactive demyelinating lesion

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1111/ncn3.12364

Cite this

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title = "A unique case with positive anti-myelin oligodendrocyte glycoprotein antibody presenting multiple brain lesions",

abstract = "The accurate diagnosis of anti-myelin oligodendrocyte glycoprotein (MOG) antibody-associated diseases is sometimes challenging due to its various central nervous system (CNS) lesions. Here, we report a 22-year-old man with positive anti-MOG antibody presenting multiple brain lesions including a brainstem tumefactive demyelinating lesion (TDL), cortical edematous lesions, and a periventricular white matter lesion. These variety of lesions made the diagnosis challenging, especially because TDL is quite rare among MOG antibody-associated disease patients. The present case suggests the importance to check anti-MOG antibody for patients presenting atypical multiple CNS lesions.",

keywords = "clinically isolated syndrome, MS and related diseases, myelin oligodendrocyte glycoprotein, neuromyelitis optica spectrum disorder, tumefactive demyelinating lesion",

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AU - Matsumoto, Namiko

AU - Sato, Kota

AU - Hishikawa, Nozomi

AU - Kawahara, Yuko

AU - Takemoto, Mami

AU - Ohta, Yasuyuki

AU - Yamashita, Toru

AU - Fujii, Kentaro

AU - Kurozumi, Kazuhiko

AU - Date, Isao

AU - Takahashi, Toshiyuki

AU - Abe, Koji

PY - 2020/3/1

Y1 - 2020/3/1

N2 - The accurate diagnosis of anti-myelin oligodendrocyte glycoprotein (MOG) antibody-associated diseases is sometimes challenging due to its various central nervous system (CNS) lesions. Here, we report a 22-year-old man with positive anti-MOG antibody presenting multiple brain lesions including a brainstem tumefactive demyelinating lesion (TDL), cortical edematous lesions, and a periventricular white matter lesion. These variety of lesions made the diagnosis challenging, especially because TDL is quite rare among MOG antibody-associated disease patients. The present case suggests the importance to check anti-MOG antibody for patients presenting atypical multiple CNS lesions.

AB - The accurate diagnosis of anti-myelin oligodendrocyte glycoprotein (MOG) antibody-associated diseases is sometimes challenging due to its various central nervous system (CNS) lesions. Here, we report a 22-year-old man with positive anti-MOG antibody presenting multiple brain lesions including a brainstem tumefactive demyelinating lesion (TDL), cortical edematous lesions, and a periventricular white matter lesion. These variety of lesions made the diagnosis challenging, especially because TDL is quite rare among MOG antibody-associated disease patients. The present case suggests the importance to check anti-MOG antibody for patients presenting atypical multiple CNS lesions.

KW - clinically isolated syndrome

KW - MS and related diseases

KW - myelin oligodendrocyte glycoprotein

KW - neuromyelitis optica spectrum disorder

KW - tumefactive demyelinating lesion

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IS - 2

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A unique case with positive anti-myelin oligodendrocyte glycoprotein antibody presenting multiple brain lesions

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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