A versatile biodegradable polymer with a thermo-reversible/irreversible transition

Fumiaki Tanimoto; Yoshiro Kitamura; Tsutomu Ono; Hidekazu Yoshizawa

doi:10.1021/am900705s

A versatile biodegradable polymer with a thermo-reversible/irreversible transition

Fumiaki Tanimoto, Yoshiro Kitamura, Tsutomu Ono, Hidekazu Yoshizawa

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

A versatile biodegradable thermoresponsive polymer was developed. The polymer has succinimide and isopropylasparamide segments and exhibits a phase transition with thermoreversibility that can be controlled by changing the polymer composition. With fewer succinimide units, the polymer exhibits the type of thermo-reversible phase transition that is characteristic of poly(N-isopropylacrylamide) (PNIPAAm). The polymer with a higher proportion of succinimide units exhibits a thermo-irreversible phase transition, resulting in the formation of nanospheres that are stable below the transition temperature. The stable nanospheres are generated by dehydration and subsequent conformational stabilization through an interaction between imide rings. This thermoirreversible phase transition in water provides a simple, oil-free preparation of biodegradable nanospheres.

Original language	English
Pages (from-to)	606-610
Number of pages	5
Journal	ACS Applied Materials and Interfaces
Volume	2
Issue number	3
DOIs	https://doi.org/10.1021/am900705s
Publication status	Published - Mar 24 2010

Keywords

Biodegradable nanosphere
Irreversible phase transition
Poly(aspartic acid)
Poly(succinimide)
Thermoresponsive polymer

ASJC Scopus subject areas

Materials Science(all)

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10.1021/am900705s

Cite this

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abstract = "A versatile biodegradable thermoresponsive polymer was developed. The polymer has succinimide and isopropylasparamide segments and exhibits a phase transition with thermoreversibility that can be controlled by changing the polymer composition. With fewer succinimide units, the polymer exhibits the type of thermo-reversible phase transition that is characteristic of poly(N-isopropylacrylamide) (PNIPAAm). The polymer with a higher proportion of succinimide units exhibits a thermo-irreversible phase transition, resulting in the formation of nanospheres that are stable below the transition temperature. The stable nanospheres are generated by dehydration and subsequent conformational stabilization through an interaction between imide rings. This thermoirreversible phase transition in water provides a simple, oil-free preparation of biodegradable nanospheres.",

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AU - Tanimoto, Fumiaki

AU - Kitamura, Yoshiro

AU - Ono, Tsutomu

AU - Yoshizawa, Hidekazu

PY - 2010/3/24

Y1 - 2010/3/24

N2 - A versatile biodegradable thermoresponsive polymer was developed. The polymer has succinimide and isopropylasparamide segments and exhibits a phase transition with thermoreversibility that can be controlled by changing the polymer composition. With fewer succinimide units, the polymer exhibits the type of thermo-reversible phase transition that is characteristic of poly(N-isopropylacrylamide) (PNIPAAm). The polymer with a higher proportion of succinimide units exhibits a thermo-irreversible phase transition, resulting in the formation of nanospheres that are stable below the transition temperature. The stable nanospheres are generated by dehydration and subsequent conformational stabilization through an interaction between imide rings. This thermoirreversible phase transition in water provides a simple, oil-free preparation of biodegradable nanospheres.

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KW - Biodegradable nanosphere

KW - Irreversible phase transition

KW - Poly(aspartic acid)

KW - Poly(succinimide)

KW - Thermoresponsive polymer

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A versatile biodegradable polymer with a thermo-reversible/irreversible transition

Abstract

Keywords

ASJC Scopus subject areas

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