A very rare case of breast cancer in a female-to-male transsexual

Yuko Katayama; Takayuki Motoki; Satoko Watanabe; Saiga Miho; Yoshihiro Kimata; Junji Matsuoka; Hiroyoshi Doihara; Yuzaburo Nanba

doi:10.1007/s12282-015-0661-4

A very rare case of breast cancer in a female-to-male transsexual

Yuko Katayama, Takayuki Motoki, Satoko Watanabe, Saiga Miho, Yoshihiro Kimata, Junji Matsuoka, Hiroyoshi Doihara, Yuzaburo Nanba

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

The incidence of breast cancer in female-to-male (FTM) transsexuals who received mastectomy and sex reassignment surgery is very rare. In fact, there is only one previous medical report of such a case. We experienced a case of an FTM transsexual who developed breast cancer 12 years after mastectomy and hysterectomy with bilateral salpingo-oophorectomy. Because he had been continuously receiving testosterone during the last 15 years and because histopathological examination revealed positive estrogen receptor and androgen receptor expression, we suggest that exogenous testosterone may have initiated the development of breast cancer via two distinct pathways. We describe the clinical course and condition of the patient and recommend that medical personnel consider the possibility of hormone-related cancer in FTM transsexuals receiving cross-sex hormones.

Original language	English
Pages (from-to)	939-944
Number of pages	6
Journal	Breast Cancer
Volume	23
Issue number	6
DOIs	https://doi.org/10.1007/s12282-015-0661-4
Publication status	Published - Nov 1 2016

Keywords

Breast cancer
Hormone therapy
Transsexual

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12282-015-0661-4

Cite this

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title = "A very rare case of breast cancer in a female-to-male transsexual",

abstract = "The incidence of breast cancer in female-to-male (FTM) transsexuals who received mastectomy and sex reassignment surgery is very rare. In fact, there is only one previous medical report of such a case. We experienced a case of an FTM transsexual who developed breast cancer 12 years after mastectomy and hysterectomy with bilateral salpingo-oophorectomy. Because he had been continuously receiving testosterone during the last 15 years and because histopathological examination revealed positive estrogen receptor and androgen receptor expression, we suggest that exogenous testosterone may have initiated the development of breast cancer via two distinct pathways. We describe the clinical course and condition of the patient and recommend that medical personnel consider the possibility of hormone-related cancer in FTM transsexuals receiving cross-sex hormones.",

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doi = "10.1007/s12282-015-0661-4",

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T1 - A very rare case of breast cancer in a female-to-male transsexual

AU - Katayama, Yuko

AU - Motoki, Takayuki

AU - Watanabe, Satoko

AU - Miho, Saiga

AU - Kimata, Yoshihiro

AU - Matsuoka, Junji

AU - Doihara, Hiroyoshi

AU - Nanba, Yuzaburo

PY - 2016/11/1

Y1 - 2016/11/1

N2 - The incidence of breast cancer in female-to-male (FTM) transsexuals who received mastectomy and sex reassignment surgery is very rare. In fact, there is only one previous medical report of such a case. We experienced a case of an FTM transsexual who developed breast cancer 12 years after mastectomy and hysterectomy with bilateral salpingo-oophorectomy. Because he had been continuously receiving testosterone during the last 15 years and because histopathological examination revealed positive estrogen receptor and androgen receptor expression, we suggest that exogenous testosterone may have initiated the development of breast cancer via two distinct pathways. We describe the clinical course and condition of the patient and recommend that medical personnel consider the possibility of hormone-related cancer in FTM transsexuals receiving cross-sex hormones.

AB - The incidence of breast cancer in female-to-male (FTM) transsexuals who received mastectomy and sex reassignment surgery is very rare. In fact, there is only one previous medical report of such a case. We experienced a case of an FTM transsexual who developed breast cancer 12 years after mastectomy and hysterectomy with bilateral salpingo-oophorectomy. Because he had been continuously receiving testosterone during the last 15 years and because histopathological examination revealed positive estrogen receptor and androgen receptor expression, we suggest that exogenous testosterone may have initiated the development of breast cancer via two distinct pathways. We describe the clinical course and condition of the patient and recommend that medical personnel consider the possibility of hormone-related cancer in FTM transsexuals receiving cross-sex hormones.

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A very rare case of breast cancer in a female-to-male transsexual

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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