TY - JOUR
T1 - Aberrant expression of the monocyte/macrophage phenotype in a human T cell line immortalized by HTLV‐I and an adult T cell leukemia/lymphoma cell line
AU - Jeon, Ho Jong
AU - Akagi, Tadaatsu
AU - Yoshino, Tadashi
AU - Takahashi, Kiyoshi
AU - Hayashi, Kazuhiko
AU - Kondo, Eisaku
AU - Sarker, Ashit Baran
AU - Teramoto, Norihiro
AU - Fujiwara, Kotaro
AU - Ohara, Nobuya
AU - Miyamoto, Kanji
PY - 1994/1
Y1 - 1994/1
N2 - An HTLV‐I‐immortalized human T cell line (JP‐2), a N‐methyl‐N′‐nitro‐N‐nitrosoguanidine‐treated JP‐2 line (JP‐2T), and an adult T cell leukemia cell line (ATL‐1T) were examined morphologically and phenotypically. All of these cell lines expressed some T cell markers, including CD4, and showed rearrangement of T cell receptor (TCR) genes, but they lacked CD3 and TCR antigens and expressed some myelomonocytic markers (CD68, HL‐21, CD15, CD16). JP‐2 cells grew in suspension, but JP‐2T and ATL‐1T cells, which mostly adhered to the surface of culture vessels, showed macrophage‐like morphological features and expressed more monocyte/macrophage markers (lysozyme, α1‐antitrypsin) and fibronectin. ATL‐1T cells transplanted into SCID mice lost the macrophage features. These results suggest that HTLV‐I infected T cells can express some macrophage features and that these cells may provide a model that will be useful in elucidating the phenotypic variability of T cell lymphomas.
AB - An HTLV‐I‐immortalized human T cell line (JP‐2), a N‐methyl‐N′‐nitro‐N‐nitrosoguanidine‐treated JP‐2 line (JP‐2T), and an adult T cell leukemia cell line (ATL‐1T) were examined morphologically and phenotypically. All of these cell lines expressed some T cell markers, including CD4, and showed rearrangement of T cell receptor (TCR) genes, but they lacked CD3 and TCR antigens and expressed some myelomonocytic markers (CD68, HL‐21, CD15, CD16). JP‐2 cells grew in suspension, but JP‐2T and ATL‐1T cells, which mostly adhered to the surface of culture vessels, showed macrophage‐like morphological features and expressed more monocyte/macrophage markers (lysozyme, α1‐antitrypsin) and fibronectin. ATL‐1T cells transplanted into SCID mice lost the macrophage features. These results suggest that HTLV‐I infected T cells can express some macrophage features and that these cells may provide a model that will be useful in elucidating the phenotypic variability of T cell lymphomas.
KW - HTLV‐I
KW - cultured cells
KW - histiocyte
KW - immunohisto‐chemistry
KW - leukemia/lymphoma
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U2 - 10.1111/j.1440-1827.1994.tb02584.x
DO - 10.1111/j.1440-1827.1994.tb02584.x
M3 - Article
C2 - 8025648
AN - SCOPUS:0028256287
SN - 1320-5463
VL - 44
SP - 39
EP - 48
JO - Pathology International
JF - Pathology International
IS - 1
ER -